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A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth.

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Title: A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth.
Authors: Tsai YT; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan., Yen MH; Division of Colorectal Surgery, Department of Surgery, Taipei Medical University Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan., Hu PJ; Division of Gastroenterology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Lee CC; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Liu CY; Ji Yan Biomedical (JY BioMed) Co., Ltd, Taipei, Taiwan., Cheng TM; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Shen HT; Ji Yan Biomedical (JY BioMed) Co., Ltd, Taipei, Taiwan; Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan., Benjamin Zhang BX; Ji Yan Biomedical (JY BioMed) Co., Ltd, Taipei, Taiwan; Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taiwan., Lee HL; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Chuang KH; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan., Yap CV; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Wang WC; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan., Wu MH; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: mhwu1015@tmu.edu.tw.
Source: Cancer letters [Cancer Lett] 2026 Jun 28; Vol. 648, pp. 218463. Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE; In Process
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  Data: A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth.
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  Data: <searchLink fieldCode="AU" term="%22Tsai+YT%22">Tsai YT</searchLink>; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+MH%22">Yen MH</searchLink>; Division of Colorectal Surgery, Department of Surgery, Taipei Medical University Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hu+PJ%22">Hu PJ</searchLink>; Division of Gastroenterology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+CC%22">Lee CC</searchLink>; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CY%22">Liu CY</searchLink>; Ji Yan Biomedical (JY BioMed) Co., Ltd, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+TM%22">Cheng TM</searchLink>; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shen+HT%22">Shen HT</searchLink>; Ji Yan Biomedical (JY BioMed) Co., Ltd, Taipei, Taiwan; Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Benjamin+Zhang+BX%22">Benjamin Zhang BX</searchLink>; Ji Yan Biomedical (JY BioMed) Co., Ltd, Taipei, Taiwan; Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+HL%22">Lee HL</searchLink>; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chuang+KH%22">Chuang KH</searchLink>; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yap+CV%22">Yap CV</searchLink>; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+WC%22">Wang WC</searchLink>; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+MH%22">Wu MH</searchLink>; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: mhwu1015@tmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%227600053%22">Cancer letters</searchLink> [Cancer Lett] 2026 Jun 28; Vol. 648, pp. 218463. <i>Date of Electronic Publication: </i>2026 Mar 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ireland%22">Elsevier Science Ireland </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7600053 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7980 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203043835%22">03043835 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Lett <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.1016/j.canlet.2026.218463
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        Text: English
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