Targeted inhibition of the CREB1-CtIP axis enhances the efficacy of abiraterone combined with radiotherapy in prostate cancer.

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Title: Targeted inhibition of the CREB1-CtIP axis enhances the efficacy of abiraterone combined with radiotherapy in prostate cancer.
Authors: Han X; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Song L; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Feng Y; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China., Wang Z; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Wang L; Department of General Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China., Liu R; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Liu Y; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Li N; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Ma S; Nanozyme Medical Center, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China., Lu F; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Yang J; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. yangjinjian2011@126.com., Huang Z; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. huangzl@zzu.edu.cn., Jia Z; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. jiazhankui@126.com.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 30; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-026-08633-0