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Antagonistic SMAD2/3 control of TIMP-1, VEGF-A, and hypoxia signaling in myofibroblasts shapes histotype-specific angiogenesis in lung cancer.

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Title: Antagonistic SMAD2/3 control of TIMP-1, VEGF-A, and hypoxia signaling in myofibroblasts shapes histotype-specific angiogenesis in lung cancer.
Authors: Díaz-Valdivia N; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain., Duch P; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain., Ikemori R; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain., Parker AL; Matrix and Metastasis Lab, Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Arshakyan M; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain., Llorente A; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain., Bernardo A; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain., Rodríguez-Rojas J; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain., Carrasco JL; Unit of Biostatistics, Department of Basic Clinical Practice, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain., Park D; Tumour Cell Biology Laboratory, The Francis Crick Institute, London, UK., Sahai E; Tumour Cell Biology Laboratory, The Francis Crick Institute, London, UK., Fillat C; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.; Department of Medicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain., Juan M; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Servei d'Immunologia, Hospital Clinic Barcelona, Barcelona, Spain., Nadal E; Preclinical and Experimental Research in Thoracic Tumors (PRETT), Oncobell, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.; Department of Medical Oncology, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Spain., Reguart N; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Thoracic Oncology Unit, Hospital Clinic Barcelona, Barcelona, Spain., Radisky DC; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Casanovas O; Tumor Angiogenesis Group. ProCURE, Catalan Institute of Oncology, Oncobell, IDIBELL, L'Hospitalet de Llobregat, Spain., Alcaraz J; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain. jalcaraz@ub.edu.; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain. jalcaraz@ub.edu.; Thoracic Oncology Unit, Hospital Clinic Barcelona, Barcelona, Spain. jalcaraz@ub.edu.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. jalcaraz@ub.edu.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 30; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
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  Data: Antagonistic SMAD2/3 control of TIMP-1, VEGF-A, and hypoxia signaling in myofibroblasts shapes histotype-specific angiogenesis in lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Díaz-Valdivia+N%22">Díaz-Valdivia N</searchLink>; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Duch+P%22">Duch P</searchLink>; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ikemori+R%22">Ikemori R</searchLink>; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Parker+AL%22">Parker AL</searchLink>; Matrix and Metastasis Lab, Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Arshakyan+M%22">Arshakyan M</searchLink>; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Llorente+A%22">Llorente A</searchLink>; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bernardo+A%22">Bernardo A</searchLink>; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Rojas+J%22">Rodríguez-Rojas J</searchLink>; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Carrasco+JL%22">Carrasco JL</searchLink>; Unit of Biostatistics, Department of Basic Clinical Practice, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Park+D%22">Park D</searchLink>; Tumour Cell Biology Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Sahai+E%22">Sahai E</searchLink>; Tumour Cell Biology Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Fillat+C%22">Fillat C</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.; Department of Medicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Juan+M%22">Juan M</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Servei d'Immunologia, Hospital Clinic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Nadal+E%22">Nadal E</searchLink>; Preclinical and Experimental Research in Thoracic Tumors (PRETT), Oncobell, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.; Department of Medical Oncology, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Reguart+N%22">Reguart N</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Thoracic Oncology Unit, Hospital Clinic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Radisky+DC%22">Radisky DC</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Casanovas+O%22">Casanovas O</searchLink>; Tumor Angiogenesis Group. ProCURE, Catalan Institute of Oncology, Oncobell, IDIBELL, L'Hospitalet de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Alcaraz+J%22">Alcaraz J</searchLink>; Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain. jalcaraz@ub.edu.; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain. jalcaraz@ub.edu.; Thoracic Oncology Unit, Hospital Clinic Barcelona, Barcelona, Spain. jalcaraz@ub.edu.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. jalcaraz@ub.edu.
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