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Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability.

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Title: Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability.
Authors: Gutierrez C; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Kwok M; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Centre for Clinical Haematology, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Ruthen N; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Waddicor P; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Curran C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Northeastern University, Boston, MA, USA., Ouspenskaia T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fu D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts Institute of Technology, Cambridge, MA, USA., Smalec B; Harvard Medical School, Boston, MA, USA., Sedor S; Harvard Medical School, Boston, MA, USA., Knisbacher BA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel., Biran A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Nagler A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Garbicz F; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Sewastianik T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Penailillo J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lucas F; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Yin S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Liani A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Northeastern University, Boston, MA, USA., Chen S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lazarian G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; INSERM, U978, Université Paris 13, Bobigny, France.; Laboratoire d'Hématologie, APHP Hôpital Avicenne, Bobigny, France., Witten E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Dangle N; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Brunsting EL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Zheng M; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Lin ES; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lee MJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Northeastern University, Boston, MA, USA., Wells B; Harvard Medical School, Boston, MA, USA., Pomerance L; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Hernández-Sánchez M; Department of Biochemistry and Molecular Biology, Pharmacy School, Universidad Complutense de Madrid, Madrid, Spain., Li S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Translational Immunogenetics Lab, Dana-Farber Cancer Institute, Boston, MA, USA., Lin Z; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Al'Khafaji A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang L; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Thakurela S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Livak KJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Translational Immunogenetics Lab, Dana-Farber Cancer Institute, Boston, MA, USA., Neuberg D; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Cymbalista F; INSERM, U978, Université Paris 13, Bobigny, France.; Laboratoire d'Hématologie, APHP Hôpital Avicenne, Bobigny, France., Getz G; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Churchman S; Harvard Medical School, Boston, MA, USA., Ten Hacken E; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Carrasco R; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Shao S; Harvard Medical School, Boston, MA, USA., Wu CJ; Harvard Medical School, Boston, MA, USA. catherine_wu@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. catherine_wu@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. catherine_wu@dfci.harvard.edu.
Source: Nature communications [Nat Commun] 2026 Mar 30; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability.
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