The NPR1 agonist antibody XXB750 in heart failure: a phase 2 randomized trial.
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| Title: | The NPR1 agonist antibody XXB750 in heart failure: a phase 2 randomized trial. |
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| Authors: | Solomon SD; The Cardiovascular Division, Mass General Brigham, Harvard Medical School, Boston, MA, USA. ssolomon@bwh.harvard.edu., McMurray JJV; University of Glasgow, Glasgow, UK., Felker GM; Duke University, Durham, NC, USA., Januzzi JL; The Cardiovascular Division, Mass General Brigham, Harvard Medical School, Boston, MA, USA., Lam CSP; Duke National University of Singapore, Singapore, Singapore., Voors AA; University of Groningen, Groningen, the Netherlands., Claggett B; The Cardiovascular Division, Mass General Brigham, Harvard Medical School, Boston, MA, USA., Nuehrenberg TG; Novartis Pharma AG, Basel, Switzerland., Rizkala AR; Novartis Pharmaceuticals, East Hanover, NJ, USA., Koch C; Novartis Pharma AG, Basel, Switzerland., Zhu W; Novartis Pharmaceuticals UK Ltd, London, UK., Lefkowitz MP; Novartis Pharmaceuticals, East Hanover, NJ, USA. |
| Source: | Nature medicine [Nat Med] 2026 May; Vol. 32 (5), pp. 1694-1700. Date of Electronic Publication: 2026 Mar 30. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II |
| Journal Info: | Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41912806 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The NPR1 agonist antibody XXB750 in heart failure: a phase 2 randomized trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Solomon+SD%22">Solomon SD</searchLink>; The Cardiovascular Division, Mass General Brigham, Harvard Medical School, Boston, MA, USA. ssolomon@bwh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22McMurray+JJV%22">McMurray JJV</searchLink>; University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Felker+GM%22">Felker GM</searchLink>; Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Januzzi+JL%22">Januzzi JL</searchLink>; The Cardiovascular Division, Mass General Brigham, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lam+CSP%22">Lam CSP</searchLink>; Duke National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Voors+AA%22">Voors AA</searchLink>; University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Claggett+B%22">Claggett B</searchLink>; The Cardiovascular Division, Mass General Brigham, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nuehrenberg+TG%22">Nuehrenberg TG</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rizkala+AR%22">Rizkala AR</searchLink>; Novartis Pharmaceuticals, East Hanover, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Koch+C%22">Koch C</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zhu+W%22">Zhu W</searchLink>; Novartis Pharmaceuticals UK Ltd, London, UK.<br /><searchLink fieldCode="AU" term="%22Lefkowitz+MP%22">Lefkowitz MP</searchLink>; Novartis Pharmaceuticals, East Hanover, NJ, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 May; Vol. 32 (5), pp. 1694-1700. <i>Date of Electronic Publication: </i>2026 Mar 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Company%22">Nature Publishing Company </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502015 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-170X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210788956%22">10788956 </searchLink><i>NLM ISO Abbreviation: </i>Nat Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41912806 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41591-026-04313-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1694 Titles: – TitleFull: The NPR1 agonist antibody XXB750 in heart failure: a phase 2 randomized trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Solomon SD – PersonEntity: Name: NameFull: McMurray JJV – PersonEntity: Name: NameFull: Felker GM – PersonEntity: Name: NameFull: Januzzi JL – PersonEntity: Name: NameFull: Lam CSP – PersonEntity: Name: NameFull: Voors AA – PersonEntity: Name: NameFull: Claggett B – PersonEntity: Name: NameFull: Nuehrenberg TG – PersonEntity: Name: NameFull: Rizkala AR – PersonEntity: Name: NameFull: Koch C – PersonEntity: Name: NameFull: Zhu W – PersonEntity: Name: NameFull: Lefkowitz MP IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1546-170X Numbering: – Type: volume Value: 32 – Type: issue Value: 5 Titles: – TitleFull: Nature medicine Type: main |
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