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Resveratrol therapy modulates inflammatory biomarkers and reverses mechanical allodynia in rats subjected to a temporomandibular joint arthritis model.

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Title: Resveratrol therapy modulates inflammatory biomarkers and reverses mechanical allodynia in rats subjected to a temporomandibular joint arthritis model.
Authors: Morais ITS; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Post-Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil., de Oliveira VF; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil., de Oliveira TC; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil., Stieven A; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Program in Medicine: Medical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil., Melo AS; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil., Caumo W; Program in Medicine: Medical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil., Stein DJ; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Program in Medicine: Medical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil., Torres ILS; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil. iltorres@hcpa.edu.br.; Post-Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. iltorres@hcpa.edu.br.; Program in Medicine: Medical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. iltorres@hcpa.edu.br.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil. iltorres@hcpa.edu.br.
Source: Inflammopharmacology [Inflammopharmacology] 2026 May; Vol. 34 (5), pp. 3277-3292. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE
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  Data: Resveratrol therapy modulates inflammatory biomarkers and reverses mechanical allodynia in rats subjected to a temporomandibular joint arthritis model.
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  Data: <searchLink fieldCode="AU" term="%22Morais+ITS%22">Morais ITS</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Post-Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+VF%22">de Oliveira VF</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+TC%22">de Oliveira TC</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil.<br /><searchLink fieldCode="AU" term="%22Stieven+A%22">Stieven A</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Program in Medicine: Medical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil.<br /><searchLink fieldCode="AU" term="%22Melo+AS%22">Melo AS</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil.<br /><searchLink fieldCode="AU" term="%22Caumo+W%22">Caumo W</searchLink>; Program in Medicine: Medical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil.<br /><searchLink fieldCode="AU" term="%22Stein+DJ%22">Stein DJ</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil.; Program in Medicine: Medical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil.<br /><searchLink fieldCode="AU" term="%22Torres+ILS%22">Torres ILS</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Hospital de Clínicas de Porto Alegre, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, Brazil. iltorres@hcpa.edu.br.; Post-Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. iltorres@hcpa.edu.br.; Program in Medicine: Medical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. iltorres@hcpa.edu.br.; Translational Nucleus: Pain Pharmacology and Neuromodulation, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n. 2350. Bairro Santa Cecília, Porto Alegre, RS, 90035-903, Brazil. iltorres@hcpa.edu.br.
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  Data: <searchLink fieldCode="JN" term="%229112626%22">Inflammopharmacology</searchLink> [Inflammopharmacology] 2026 May; Vol. 34 (5), pp. 3277-3292. <i>Date of Electronic Publication: </i>2026 Mar 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Birkhäuser%22">Birkhäuser </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9112626 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1568-5608 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209254692%22">09254692 </searchLink><i>NLM ISO Abbreviation: </i>Inflammopharmacology <i>Subsets: </i>MEDLINE
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      – TitleFull: Resveratrol therapy modulates inflammatory biomarkers and reverses mechanical allodynia in rats subjected to a temporomandibular joint arthritis model.
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              Text: 2026 May
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