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High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics.

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Title: High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics.
Authors: Edizcan Z; Institute for Systems Medicine with Focus on Organ Interaction, University Hospital RWTH Aachen, Aachen, Germany., Schaller S; ESQlabs GmbH, Saterland, Germany., Kuepfer L; Institute for Systems Medicine with Focus on Organ Interaction, University Hospital RWTH Aachen, Aachen, Germany., Geci R; Institute for Systems Medicine with Focus on Organ Interaction, University Hospital RWTH Aachen, Aachen, Germany. rgeci@ukaachen.de.
Source: Archives of toxicology [Arch Toxicol] 2026 Jun; Vol. 100 (6), pp. 2421-2432. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Edizcan+Z%22">Edizcan Z</searchLink>; Institute for Systems Medicine with Focus on Organ Interaction, University Hospital RWTH Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Schaller+S%22">Schaller S</searchLink>; ESQlabs GmbH, Saterland, Germany.<br /><searchLink fieldCode="AU" term="%22Kuepfer+L%22">Kuepfer L</searchLink>; Institute for Systems Medicine with Focus on Organ Interaction, University Hospital RWTH Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Geci+R%22">Geci R</searchLink>; Institute for Systems Medicine with Focus on Organ Interaction, University Hospital RWTH Aachen, Aachen, Germany. rgeci@ukaachen.de.
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  Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2026 Jun; Vol. 100 (6), pp. 2421-2432. <i>Date of Electronic Publication: </i>2026 Mar 31.
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        Value: 10.1007/s00204-026-04357-4
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      – Code: eng
        Text: English
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        StartPage: 2421
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      – TitleFull: High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics.
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            NameFull: Edizcan Z
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            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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              Value: 100
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              Value: 6
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