The MALAT1-EZH2 axis regulates PRC2 activity and promotes the mesenchymal phenotype in pediatric atypical teratoid/rhabdoid tumors.

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Title: The MALAT1-EZH2 axis regulates PRC2 activity and promotes the mesenchymal phenotype in pediatric atypical teratoid/rhabdoid tumors.
Authors: Gurbuz M; Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, Gorukle, Bursa, 16059, Türkiye., Tekin C; Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, Gorukle, Bursa, 16059, Türkiye., Ercelik M; Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, Gorukle, Bursa, 16059, Türkiye., Koc SA; Department of Molecular Biology and Genetics, Arts and Science Faculty, Balikesir University, Balikesir, Türkiye., Kockar F; Department of Molecular Biology and Genetics, Arts and Science Faculty, Balikesir University, Balikesir, Türkiye., Eser P; Department of Neurosurgery, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye., Taskapilioglu MO; Department of Neurosurgery, Faculty of Medicine, Istanbul Yeni Yuzyıl University, Istanbul, Turkey., Tezcan G; Department of Fundamental Sciences, Faculty of Dentistry, Bursa Uludag University, Bursa, Türkiye., Erbaykent B; Division of Molecular Biology & Genetics, School of Arts & Sciences, Bursa Uludag University, Bursa, Türkiye., Bekar A; Department of Neurosurgery, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye., Kocaeli H; Department of Neurosurgery, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye., Ozsen M; Department of Pathology, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye., Karabaglı P; Department of Pathology, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Türkiye., Karabaglı H; Department of Neurosurgery, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Türkiye., Bayrak BY; Department of Pathology, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye., Etus V; Department of Neurosurgery, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye., Tunca B; Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, Gorukle, Bursa, 16059, Türkiye. btunca@uludag.edu.tr.
Source: Journal of neuro-oncology [J Neurooncol] 2026 Mar 31; Vol. 177 (2). Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE
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  Data: The MALAT1-EZH2 axis regulates PRC2 activity and promotes the mesenchymal phenotype in pediatric atypical teratoid/rhabdoid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Gurbuz+M%22">Gurbuz M</searchLink>; Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, Gorukle, Bursa, 16059, Türkiye.<br /><searchLink fieldCode="AU" term="%22Tekin+C%22">Tekin C</searchLink>; Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, Gorukle, Bursa, 16059, Türkiye.<br /><searchLink fieldCode="AU" term="%22Ercelik+M%22">Ercelik M</searchLink>; Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, Gorukle, Bursa, 16059, Türkiye.<br /><searchLink fieldCode="AU" term="%22Koc+SA%22">Koc SA</searchLink>; Department of Molecular Biology and Genetics, Arts and Science Faculty, Balikesir University, Balikesir, Türkiye.<br /><searchLink fieldCode="AU" term="%22Kockar+F%22">Kockar F</searchLink>; Department of Molecular Biology and Genetics, Arts and Science Faculty, Balikesir University, Balikesir, Türkiye.<br /><searchLink fieldCode="AU" term="%22Eser+P%22">Eser P</searchLink>; Department of Neurosurgery, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye.<br /><searchLink fieldCode="AU" term="%22Taskapilioglu+MO%22">Taskapilioglu MO</searchLink>; Department of Neurosurgery, Faculty of Medicine, Istanbul Yeni Yuzyıl University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Tezcan+G%22">Tezcan G</searchLink>; Department of Fundamental Sciences, Faculty of Dentistry, Bursa Uludag University, Bursa, Türkiye.<br /><searchLink fieldCode="AU" term="%22Erbaykent+B%22">Erbaykent B</searchLink>; Division of Molecular Biology & Genetics, School of Arts & Sciences, Bursa Uludag University, Bursa, Türkiye.<br /><searchLink fieldCode="AU" term="%22Bekar+A%22">Bekar A</searchLink>; Department of Neurosurgery, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye.<br /><searchLink fieldCode="AU" term="%22Kocaeli+H%22">Kocaeli H</searchLink>; Department of Neurosurgery, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye.<br /><searchLink fieldCode="AU" term="%22Ozsen+M%22">Ozsen M</searchLink>; Department of Pathology, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye.<br /><searchLink fieldCode="AU" term="%22Karabaglı+P%22">Karabaglı P</searchLink>; Department of Pathology, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Türkiye.<br /><searchLink fieldCode="AU" term="%22Karabaglı+H%22">Karabaglı H</searchLink>; Department of Neurosurgery, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Türkiye.<br /><searchLink fieldCode="AU" term="%22Bayrak+BY%22">Bayrak BY</searchLink>; Department of Pathology, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.<br /><searchLink fieldCode="AU" term="%22Etus+V%22">Etus V</searchLink>; Department of Neurosurgery, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye.<br /><searchLink fieldCode="AU" term="%22Tunca+B%22">Tunca B</searchLink>; Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, Gorukle, Bursa, 16059, Türkiye. btunca@uludag.edu.tr.
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      – TitleFull: The MALAT1-EZH2 axis regulates PRC2 activity and promotes the mesenchymal phenotype in pediatric atypical teratoid/rhabdoid tumors.
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