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Radiofrequency Ablation and Chemotherapy vs Chemotherapy Only in Locally Advanced Pancreatic Cancer: The PELICAN Randomized Clinical Trial.

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Title: Radiofrequency Ablation and Chemotherapy vs Chemotherapy Only in Locally Advanced Pancreatic Cancer: The PELICAN Randomized Clinical Trial.
Authors: Seelen LWF; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Brada LJH; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Walma MS; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Rombouts SJE; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Braat MN; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands., Bollen TL; Department of Radiology, St Antonius Hospital, Nieuwegein, the Netherlands., Borel Rinkes IH; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Bruijnen RCG; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands., Busch OR; Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Cancer Center Amsterdam, Amsterdam, the Netherlands., Cirkel GA; Department of Medical Oncology, Regional Academic Cancer Center Utrecht, Meander Medical Center Amersfoort, University Medical Center, Utrecht, the Netherlands., Daamen LA; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.; Department of Radiation Oncology, UMC Utrecht Cancer Center, Utrecht, the Netherlands., Daams F; Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Cancer Center Amsterdam, Amsterdam, the Netherlands., van Dam RM; Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands., van Delden OM; Cancer Center Amsterdam, Amsterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Cancer Center, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., Derksen WJM; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Festen S; Department of Surgery, OLVG, Amsterdam, the Netherlands., Groothuis K; Clinical Research Department, Comprehensive Cancer Organisation the Netherlands, Nijmegen, the Netherlands., Hagendoorn J; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., de Hingh IHJT; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands., D'Hondt M; Department of Surgery, AZ Groeninge, Kortrijk, Belgium., Liem MSL; Department of Surgery, Medisch Spectrum Twente, Enschede, the Netherlands., van Lienden KP; Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands., Los M; Department of Medical Oncology, Regional Academic Cancer Center Utrecht, St Antonius Hospital Nieuwegein, University Medical Center, Utrecht, the Netherlands., de Meijer VE; Department of Surgery, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands., Mekenkamp LJM; Department of Medical Oncology, Medisch Spectrum Twente, Enschede, the Netherlands., Nijkamp MW; Department of Surgery, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands., Nio CY; Cancer Center Amsterdam, Amsterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Cancer Center, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., Pando E; Department of Hepato-Pancreato-Biliary and Transplant Surgery Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain., Patijn GA; Department of Surgery, Isala Clinics, Zwolle, the Netherlands., Polée MB; Department of Medical Oncology, Medical Center Leeuwarden, Leeuwarden, the Netherlands., Te Riele WW; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Roeyen G; Department of Hepato-Pancreato-Biliary, Endocrine, and Transplantation Surgery, Antwerp University Hospital, Edegem, Belgium., Stommel MWJ; Department of Surgery, Radboud University Medical Center, Nijmegen, the Netherlands., de Vos-Geelen J; Department of Internal Medicine, Division of Medical Oncology, GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Center, the Netherlands., de Vries JJ; Department of Radiology, OLVG, Amsterdam, the Netherlands., Wessels FJ; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands., Wilmink JW; Cancer Center Amsterdam, Amsterdam, the Netherlands.; Amsterdam UMC, location University of Amsterdam, Department of Medical Oncology, Amsterdam, the Netherlands., van de Ven PM; Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, the Netherlands., Besselink MG; Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Cancer Center Amsterdam, Amsterdam, the Netherlands., van Santvoort HC; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Molenaar IQ; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.
Corporate Authors: Dutch Pancreatic Cancer Group
Source: JAMA network open [JAMA Netw Open] 2026 Mar 02; Vol. 9 (3), pp. e263861. Date of Electronic Publication: 2026 Mar 02.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Radiofrequency Ablation and Chemotherapy vs Chemotherapy Only in Locally Advanced Pancreatic Cancer: The PELICAN Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Seelen+LWF%22">Seelen LWF</searchLink>; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Brada+LJH%22">Brada LJH</searchLink>; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Walma+MS%22">Walma MS</searchLink>; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rombouts+SJE%22">Rombouts SJE</searchLink>; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Braat+MN%22">Braat MN</searchLink>; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bollen+TL%22">Bollen TL</searchLink>; Department of Radiology, St Antonius Hospital, Nieuwegein, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Borel+Rinkes+IH%22">Borel Rinkes IH</searchLink>; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bruijnen+RCG%22">Bruijnen RCG</searchLink>; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Busch+OR%22">Busch OR</searchLink>; Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Cancer Center Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Cirkel+GA%22">Cirkel GA</searchLink>; Department of Medical Oncology, Regional Academic Cancer Center Utrecht, Meander Medical Center Amersfoort, University Medical Center, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Daamen+LA%22">Daamen LA</searchLink>; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.; Department of Radiation Oncology, UMC Utrecht Cancer Center, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Daams+F%22">Daams F</searchLink>; Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Cancer Center Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Dam+RM%22">van Dam RM</searchLink>; Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Delden+OM%22">van Delden OM</searchLink>; Cancer Center Amsterdam, Amsterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Cancer Center, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Derksen+WJM%22">Derksen WJM</searchLink>; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Festen+S%22">Festen S</searchLink>; Department of Surgery, OLVG, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Groothuis+K%22">Groothuis K</searchLink>; Clinical Research Department, Comprehensive Cancer Organisation the Netherlands, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hagendoorn+J%22">Hagendoorn J</searchLink>; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Hingh+IHJT%22">de Hingh IHJT</searchLink>; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22D'Hondt+M%22">D'Hondt M</searchLink>; 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Department of Surgery, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nio+CY%22">Nio CY</searchLink>; Cancer Center Amsterdam, Amsterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Cancer Center, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pando+E%22">Pando E</searchLink>; Department of Hepato-Pancreato-Biliary and Transplant Surgery Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Patijn+GA%22">Patijn GA</searchLink>; Department of Surgery, Isala Clinics, Zwolle, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Polée+MB%22">Polée MB</searchLink>; Department of Medical Oncology, Medical Center Leeuwarden, Leeuwarden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Te+Riele+WW%22">Te Riele WW</searchLink>; 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Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.
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