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Safety, Tolerability, and Pharmacokinetics of GMDTC for Cadmium Poisoning: A Randomized Phase 1a/1b Trial.

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Title: Safety, Tolerability, and Pharmacokinetics of GMDTC for Cadmium Poisoning: A Randomized Phase 1a/1b Trial.
Authors: Ren X; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.; School of Public Health, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China., Hu W; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China., Deng X; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China., Ma R; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China., Pei F; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China., Chen X; School of Public Health, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China., Wang X; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China., Tang J; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China., Lai Y; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China., Pan S; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China., Zhong Z; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China., Fu S; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China., Yuan H; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China., Yuan J; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China., Huang C; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China., Zeng Y; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China., Ying X; School of Public Health, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China., Dong G; School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China., Zhang J; School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China., Zhao J; Research Center of Occupational Medicine, Peking University Third Hospital, Beijing, China., Lin K; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.; Department of Psychiatry and Behavioral Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, China., Tang X; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2026 Jul; Vol. 120 (1), pp. 160-167. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety, Tolerability, and Pharmacokinetics of GMDTC for Cadmium Poisoning: A Randomized Phase 1a/1b Trial.
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  Data: <searchLink fieldCode="AU" term="%22Ren+X%22">Ren X</searchLink>; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.; School of Public Health, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Hu+W%22">Hu W</searchLink>; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Deng+X%22">Deng X</searchLink>; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Ma+R%22">Ma R</searchLink>; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Pei+F%22">Pei F</searchLink>; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; School of Public Health, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Tang+J%22">Tang J</searchLink>; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Lai+Y%22">Lai Y</searchLink>; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Pan+S%22">Pan S</searchLink>; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhong+Z%22">Zhong Z</searchLink>; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Fu+S%22">Fu S</searchLink>; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Yuan+H%22">Yuan H</searchLink>; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Yuan+J%22">Yuan J</searchLink>; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Zeng+Y%22">Zeng Y</searchLink>; Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Ying+X%22">Ying X</searchLink>; School of Public Health, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Dong+G%22">Dong G</searchLink>; School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Research Center of Occupational Medicine, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.; Department of Psychiatry and Behavioral Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Tang+X%22">Tang X</searchLink>; Guangdong Jianersheng Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong, China.
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  Data: <searchLink fieldCode="JN" term="%220372741%22">Clinical pharmacology and therapeutics</searchLink> [Clin Pharmacol Ther] 2026 Jul; Vol. 120 (1), pp. 160-167. <i>Date of Electronic Publication: </i>2026 Mar 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372741 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-6535 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200099236%22">00099236 </searchLink><i>NLM ISO Abbreviation: </i>Clin Pharmacol Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1002/cpt.70275
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              Text: 2026 Jul
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