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Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases.

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Title: Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases.
Authors: Ali M; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA., Timsina J; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA., Xu Y; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA., Chen Y; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA., Gong K; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA., Western D; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA., Heo G; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA., Liu M; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA., Budde J; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA., Pottier C; Department of Neurology, Washington University, St. Louis, MO 63110, USA., Schindler SE; Department of Neurology, Washington University, St. Louis, MO 63110, USA., Morris JC; Department of Neurology, Washington University, St. Louis, MO 63110, USA., Holtzman DM; Department of Neurology, Washington University, St. Louis, MO 63110, USA., Puerta R; ACE Alzheimer Center Barcelona, Barcelona, Spain., Cano A; ACE Alzheimer Center Barcelona, Barcelona, Spain., Boada M; ACE Alzheimer Center Barcelona, Barcelona, Spain., Fernandez MV; ACE Alzheimer Center Barcelona, Barcelona, Spain., Ruiz A; ACE Alzheimer Center Barcelona, Barcelona, Spain., Aguilar M; Fundació Docència i Recerca Mútua de Terrassa, Terrassa, Barcelona, Spain., Alvarez I; Fundació Docència i Recerca Mútua de Terrassa, Terrassa, Barcelona, Spain., Pastor P; Fundació Docència i Recerca Mútua de Terrassa, Terrassa, Barcelona, Spain., Perlmutter JS; Department of Neurology, Washington University, St. Louis, MO 63110, USA., Campbell MC; Department of Neurology, Washington University, St. Louis, MO 63110, USA., Kotzbauer PT; Department of Neurology, Washington University, St. Louis, MO 63110, USA., Oh HS; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Wilson EN; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA., Guen YL; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA., Tarawneh R; Department of Neurology, Saint Louis University, St. Louis, MO 63110, USA., Wyss-Coray T; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA., Sung YJ; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA., Ibanez L; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA; Department of Neurology, Washington University, St. Louis, MO 63110, USA., Cruchaga C; Department of Psychiatry, Washington University, St. Louis, MO 63110, USA; Department of Neurology, Washington University, St. Louis, MO 63110, USA. Electronic address: cruchagac@wustl.edu.
Corporate Authors: Knight Alzheimer Disease Research Center (Knight-ADRC), Alzheimer Disease Neuroimaging Initiative (ADNI), Fundació ACE Alzheimer Center Barcelona (FACE), Barcelona-1, Stanford Alzheimer Disease Research Center (Stanford-ADRC), Global Neurodegeneration Proteomics Consortium (GNPC)
Source: Neuron [Neuron] 2026 Jul 15; Vol. 114 (14), pp. 2549-2565.e7. Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
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  Data: Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases.
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  Data: <searchLink fieldCode="JN" term="%228809320%22">Neuron</searchLink> [Neuron] 2026 Jul 15; Vol. 114 (14), pp. 2549-2565.e7. <i>Date of Electronic Publication: </i>2026 Mar 30.
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