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A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy.

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Title: A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy.
Authors: Zhang Z; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ho YJ; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fang X; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kim M; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Li M; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Luan W; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hinterleitner C; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Haubner S; Columbia Initiative in Cell Engineering and Therapy, Department of Medicine, Columbia University, New York, NY, USA., Kogel F; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pratt EC; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ozcelik E; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Reyes J; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jiang Q; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yang VW; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chen YJ; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wang T; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Liu H; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Hu H; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Zhuang X; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Park J; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Paffenholz SV; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA., Chen K; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chang Q; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kulick A; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zhang J; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chan E; Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rosiek E; Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fan N; Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Williams RA; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wang AC; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA., Freeman S; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tian S; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gunset G; Columbia Initiative in Cell Engineering and Therapy, Department of Medicine, Columbia University, New York, NY, USA., Garcia Angus A; Columbia Initiative in Cell Engineering and Therapy, Department of Medicine, Columbia University, New York, NY, USA., Lecomte N; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yildirim SY; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ali E; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wu M; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Miranda IC; Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY, USA., Antonescu CR; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Basturk O; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tarcan Z; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rekhtman N; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wilson C; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Basar M; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sauter JL; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Al-Ahmadie HA; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Singer S; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Iacobuzio-Donahue C; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rudin C; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., de Stanchina E; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ganesh K; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Romesser PB; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Weigelt B; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Huh DD; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Leibold J; Cluster of Excellence iFIT (EXC 2180) 'Image-guided and Functionally Instructed Tumor Therapies', Department of Medical Oncology and Pneumology, University Children's Hospital Tübingen, Germany., Feucht J; Cluster of Excellence iFIT, (EXC 2180) 'Image-guided and Functionally Instructed Tumor Therapies', University Children's Hospital Tübingen, Tübingen, Germany., Vázquez-García I; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pathology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bott MJ; Thoracic Service, Department of Surgery, Fiona and Stanley Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Zamarin D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shah SP; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lewis JS; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Amor C; Cold Spring Harbor Laboratory, New York, NY, USA., Pe'er D; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mansilla-Soto J; Departments of Immunology, Bioengineering, Blood and Marrow Transplant and Cellular Immunotherapies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Filliol A; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: filliola@mskcc.org., Sadelain M; Columbia Initiative in Cell Engineering and Therapy, Department of Medicine, Columbia University, New York, NY, USA. Electronic address: mws2188@cumc.columbia.edu., Lowe SW; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: lowes@mskcc.org.
Source: Cell [Cell] 2026 May 14; Vol. 189 (10), pp. 2898-2917.e42. Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy.
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          Dates:
            – D: 14
              M: 05
              Text: 2026 May 14
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1097-4172
          Numbering:
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              Value: 189
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: Cell
              Type: main
ResultId 1