View in EDS HTML Full Text PDF Full Text

A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.

Saved in:
Bibliographic Details
Title: A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.
Authors: Mirfakhar FS; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Marsh JA; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Sato C; Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.; Tracy Family Stable Isotope Labeling Quantitation Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Schache KJ; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Minaya MA; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Dolle RE; Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Pak SC; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Silverman GA; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Perlmutter DH; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Macauley SL; Departments of Physiology and Neuroscience, University of Kentucky, Lexington, KY, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Karch CM; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. karchc@wustl.edu.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. karchc@wustl.edu.
Source: Nature communications [Nat Commun] 2026 Mar 31; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41916975
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Mirfakhar+FS%22">Mirfakhar FS</searchLink>; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Marsh+JA%22">Marsh JA</searchLink>; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Sato+C%22">Sato C</searchLink>; Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.; Tracy Family Stable Isotope Labeling Quantitation Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Schache+KJ%22">Schache KJ</searchLink>; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Minaya+MA%22">Minaya MA</searchLink>; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Dolle+RE%22">Dolle RE</searchLink>; Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Pak+SC%22">Pak SC</searchLink>; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Silverman+GA%22">Silverman GA</searchLink>; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Perlmutter+DH%22">Perlmutter DH</searchLink>; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Macauley+SL%22">Macauley SL</searchLink>; Departments of Physiology and Neuroscience, University of Kentucky, Lexington, KY, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Karch+CM%22">Karch CM</searchLink>; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. karchc@wustl.edu.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. karchc@wustl.edu.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Mar 31; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 31.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41916975
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-026-70473-5
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Mirfakhar FS
      – PersonEntity:
          Name:
            NameFull: Marsh JA
      – PersonEntity:
          Name:
            NameFull: Sato C
      – PersonEntity:
          Name:
            NameFull: Schache KJ
      – PersonEntity:
          Name:
            NameFull: Minaya MA
      – PersonEntity:
          Name:
            NameFull: Dolle RE
      – PersonEntity:
          Name:
            NameFull: Pak SC
      – PersonEntity:
          Name:
            NameFull: Silverman GA
      – PersonEntity:
          Name:
            NameFull: Perlmutter DH
      – PersonEntity:
          Name:
            NameFull: Macauley SL
      – PersonEntity:
          Name:
            NameFull: Karch CM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 31
              M: 03
              Text: 2026 Mar 31
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1