A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia. - Mirfakhar FS; Marsh JA; Sato C; Schache KJ; Minaya MA; Dolle RE; Pak SC; Silverman GA; Perlmutter DH; Macauley SL; Karch CM (Nature communications, 2026)