A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.
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| Title: | A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia. |
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| Authors: | Mirfakhar FS; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Marsh JA; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Sato C; Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.; Tracy Family Stable Isotope Labeling Quantitation Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Schache KJ; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Minaya MA; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Dolle RE; Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Pak SC; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Silverman GA; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Perlmutter DH; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Macauley SL; Departments of Physiology and Neuroscience, University of Kentucky, Lexington, KY, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Karch CM; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. karchc@wustl.edu.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. karchc@wustl.edu. |
| Source: | Nature communications [Nat Commun] 2026 Mar 31; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 31. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-70473-5 |
