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Bcl-xL blockade targets neutrophils and synergizes with chemotherapy in lung squamous cell carcinoma.

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Title: Bcl-xL blockade targets neutrophils and synergizes with chemotherapy in lung squamous cell carcinoma.
Authors: Mayet A; Laboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), 6041, Gosselies, Belgium.; Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium., Parma B; Laboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), 6041, Gosselies, Belgium.; Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium., Lécuyer D; Laboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), 6041, Gosselies, Belgium.; Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium.; Division of Thoracic Surgery, Department of Surgery, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.; Agora Cancer Research Center, and Swiss Cancer Center Léman, Lausanne, Switzerland., Defruit A; Laboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), 6041, Gosselies, Belgium.; Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium., Rana S; Laboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), 6041, Gosselies, Belgium.; Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium., Bodac A; Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Demetter P; Cerba Path, Division CMP, 1070, Bruxelles, Belgium., Denanglaire S; Laboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), 6041, Gosselies, Belgium., Ireland AS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, 27708, USA., Brandão M; Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium.; Thoracic Oncology Functional Unit, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium., Berghmans T; Thoracic Oncology Functional Unit, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium., Andris F; Laboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), 6041, Gosselies, Belgium., Goriely S; Laboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), 6041, Gosselies, Belgium., Perentes JY; Division of Thoracic Surgery, Department of Surgery, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.; Agora Cancer Research Center, and Swiss Cancer Center Léman, Lausanne, Switzerland., Oliver TG; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, 27708, USA., Meylan E; Laboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium. Meylan.Etienne@chuv.ch.; ULB Center for Research in Immunology (U-CRI), 6041, Gosselies, Belgium. Meylan.Etienne@chuv.ch.; Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium. Meylan.Etienne@chuv.ch.; Division of Thoracic Surgery, Department of Surgery, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland. Meylan.Etienne@chuv.ch.; Agora Cancer Research Center, and Swiss Cancer Center Léman, Lausanne, Switzerland. Meylan.Etienne@chuv.ch.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1625-1647. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.1038/s44321-026-00401-z