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Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis.

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Title: Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis.
Authors: Favreau C; Université Côte d'Azur, INSERM, C3M, Nice, France., Bourgoin M; Université Côte d'Azur, INSERM, C3M, Nice, France., Savy C; Université Côte d'Azur, INSERM, C3M, Nice, France., Botton T; Université Côte d'Azur, INSERM, C3M, Nice, France., Bailly S; Université Côte d'Azur, CRNS, ICN UMR 7272, Nice, France., Granger F; Plateforme de biologie structurale intégrée, CBI-IGBMC, CNRS UMR 7104 - Inserm U 1258 FR-Université de Strasbourg, Illkirch, France., Birck C; Plateforme de biologie structurale intégrée, CBI-IGBMC, CNRS UMR 7104 - Inserm U 1258 FR-Université de Strasbourg, Illkirch, France., Zerhouni M; Université Côte d'Azur, INSERM, C3M, Nice, France., Kerreneur E; Université Côte d'Azur, INSERM, C3M, Nice, France., Rivault A; Université Côte d'Azur, INSERM, C3M, Nice, France.; Université Côte d'Azur, CRNS, ICN UMR 7272, Nice, France., Vigroux A; Université Côte d'Azur, CRNS, ICN UMR 7272, Nice, France., Dussart-Gautheret J; Université Côte d'Azur, CRNS, ICN UMR 7272, Nice, France., Arcangeli ML; Université Côte d'Azur, INSERM, C3M, Nice, France., Poterszman A; Plateforme de biologie structurale intégrée, CBI-IGBMC, CNRS UMR 7104 - Inserm U 1258 FR-Université de Strasbourg, Illkirch, France., Cluzeau T; Université Côte d'Azur, INSERM, C3M, Nice, France.; Université Nice Côte d'Azur, CHU de Nice, Nice, France., Rocchi S; Université Côte d'Azur, INSERM, C3M, Nice, France., Jacquel A; Université Côte d'Azur, INSERM, C3M, Nice, France., Benhida R; Université Côte d'Azur, CRNS, ICN UMR 7272, Nice, France., Auberger P; Université Côte d'Azur, INSERM, C3M, Nice, France., Martin AR; Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, Montpellier, France. anthony.martin@umontpellier.fr., Robert G; Université Côte d'Azur, INSERM, C3M, Nice, France. guillaume.robert@univ-cotedazur.fr.
Source: Experimental hematology & oncology [Exp Hematol Oncol] 2026 Mar 31; Vol. 15 (1). Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101590676 Publication Model: Electronic Cited Medium: Print ISSN: 2162-3619 (Print) Linking ISSN: 21623619 NLM ISO Abbreviation: Exp Hematol Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Favreau+C%22">Favreau C</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Bourgoin+M%22">Bourgoin M</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Savy+C%22">Savy C</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Botton+T%22">Botton T</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Bailly+S%22">Bailly S</searchLink>; Université Côte d'Azur, CRNS, ICN UMR 7272, Nice, France.<br /><searchLink fieldCode="AU" term="%22Granger+F%22">Granger F</searchLink>; Plateforme de biologie structurale intégrée, CBI-IGBMC, CNRS UMR 7104 - Inserm U 1258 FR-Université de Strasbourg, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Birck+C%22">Birck C</searchLink>; Plateforme de biologie structurale intégrée, CBI-IGBMC, CNRS UMR 7104 - Inserm U 1258 FR-Université de Strasbourg, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Zerhouni+M%22">Zerhouni M</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Kerreneur+E%22">Kerreneur E</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Rivault+A%22">Rivault A</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.; Université Côte d'Azur, CRNS, ICN UMR 7272, Nice, France.<br /><searchLink fieldCode="AU" term="%22Vigroux+A%22">Vigroux A</searchLink>; Université Côte d'Azur, CRNS, ICN UMR 7272, Nice, France.<br /><searchLink fieldCode="AU" term="%22Dussart-Gautheret+J%22">Dussart-Gautheret J</searchLink>; Université Côte d'Azur, CRNS, ICN UMR 7272, Nice, France.<br /><searchLink fieldCode="AU" term="%22Arcangeli+ML%22">Arcangeli ML</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Poterszman+A%22">Poterszman A</searchLink>; Plateforme de biologie structurale intégrée, CBI-IGBMC, CNRS UMR 7104 - Inserm U 1258 FR-Université de Strasbourg, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Cluzeau+T%22">Cluzeau T</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.; Université Nice Côte d'Azur, CHU de Nice, Nice, France.<br /><searchLink fieldCode="AU" term="%22Rocchi+S%22">Rocchi S</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Jacquel+A%22">Jacquel A</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Benhida+R%22">Benhida R</searchLink>; Université Côte d'Azur, CRNS, ICN UMR 7272, Nice, France.<br /><searchLink fieldCode="AU" term="%22Auberger+P%22">Auberger P</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Martin+AR%22">Martin AR</searchLink>; Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, Montpellier, France. anthony.martin@umontpellier.fr.<br /><searchLink fieldCode="AU" term="%22Robert+G%22">Robert G</searchLink>; Université Côte d'Azur, INSERM, C3M, Nice, France. guillaume.robert@univ-cotedazur.fr.
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  Data: <searchLink fieldCode="JN" term="%22101590676%22">Experimental hematology & oncology</searchLink> [Exp Hematol Oncol] 2026 Mar 31; Vol. 15 (1). <i>Date of Electronic Publication: </i>2026 Mar 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101590676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2162-3619 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221623619%22">21623619 </searchLink><i>NLM ISO Abbreviation: </i>Exp Hematol Oncol <i>Subsets: </i>PubMed not MEDLINE
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