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Spatial multi-omics characterization of neuroblastoma reveals ferroptosis-associated metabolic features in high-risk tumors.

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Title: Spatial multi-omics characterization of neuroblastoma reveals ferroptosis-associated metabolic features in high-risk tumors.
Authors: Tu C; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia., Tan CW; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, 3010, Australia., Monkman J; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia., Almeida AC; Laboratório de Patologia Experimental, PPGCS, Pontifícia Universidade Católica do Paraná, Curitiba, 80215-901, Brazil., Antonio-Carreon G; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia., Omer N; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.; Queensland Children's Hospital, Brisbane, QLD, 4101, Australia., Hull G; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia., Chung K; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.; Queensland Children's Hospital, Brisbane, QLD, 4101, Australia., Mehdi AM; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.; Data Science, Collaborative Research Platform, Woolloongabba, UQ, QLD, 4102, Australia., Salerno A; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia.; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, 2052, Australia., Vittorio O; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia.; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, 2052, Australia., Mayer A; Enable Medicine LLC, Menlo Park, CA, 94025-94028, USA., Machado-Souza C; Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Paraná, 80250-060, Brazil., Jayabalan N; Centre for Biomedical Technologies, Queensland University of Technology, Kelvin Grove, QLD, 4059, Australia., Toh YC; Centre for Biomedical Technologies, Queensland University of Technology, Kelvin Grove, QLD, 4059, Australia., Hon HN; School of Pharmacy, Monash University Malaysia, Subang Jaya, 47500, Malaysia., de Almeida Brehm Pinhatti F; Laboratório de Patologia Experimental, PPGCS, Pontifícia Universidade Católica do Paraná, Curitiba, 80215-901, Brazil., Elifio-Esposito S; Laboratório de Patologia Experimental, PPGCS, Pontifícia Universidade Católica do Paraná, Curitiba, 80215-901, Brazil., Nicholls W; Queensland Children's Hospital, Brisbane, QLD, 4101, Australia., de Noronha L; Laboratório de Patologia Experimental, PPGCS, Pontifícia Universidade Católica do Paraná, Curitiba, 80215-901, Brazil., Kulasinghe A; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia., Souza-Fonseca-Guimaraes F; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia. f.guimaraes@uq.edu.au.
Source: Genome medicine [Genome Med] 2026 Mar 31; Vol. 18 (1). Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Spatial multi-omics characterization of neuroblastoma reveals ferroptosis-associated metabolic features in high-risk tumors.
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  Data: <searchLink fieldCode="AU" term="%22Tu+C%22">Tu C</searchLink>; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Tan+CW%22">Tan CW</searchLink>; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Monkman+J%22">Monkman J</searchLink>; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Almeida+AC%22">Almeida AC</searchLink>; Laboratório de Patologia Experimental, PPGCS, Pontifícia Universidade Católica do Paraná, Curitiba, 80215-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Antonio-Carreon+G%22">Antonio-Carreon G</searchLink>; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Omer+N%22">Omer N</searchLink>; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.; Queensland Children's Hospital, Brisbane, QLD, 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Hull+G%22">Hull G</searchLink>; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Chung+K%22">Chung K</searchLink>; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.; Queensland Children's Hospital, Brisbane, QLD, 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Mehdi+AM%22">Mehdi AM</searchLink>; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.; Data Science, Collaborative Research Platform, Woolloongabba, UQ, QLD, 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Salerno+A%22">Salerno A</searchLink>; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia.; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Vittorio+O%22">Vittorio O</searchLink>; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia.; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Mayer+A%22">Mayer A</searchLink>; Enable Medicine LLC, Menlo Park, CA, 94025-94028, USA.<br /><searchLink fieldCode="AU" term="%22Machado-Souza+C%22">Machado-Souza C</searchLink>; Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Paraná, 80250-060, Brazil.<br /><searchLink fieldCode="AU" term="%22Jayabalan+N%22">Jayabalan N</searchLink>; Centre for Biomedical Technologies, Queensland University of Technology, Kelvin Grove, QLD, 4059, Australia.<br /><searchLink fieldCode="AU" term="%22Toh+YC%22">Toh YC</searchLink>; Centre for Biomedical Technologies, Queensland University of Technology, Kelvin Grove, QLD, 4059, Australia.<br /><searchLink fieldCode="AU" term="%22Hon+HN%22">Hon HN</searchLink>; School of Pharmacy, Monash University Malaysia, Subang Jaya, 47500, Malaysia.<br /><searchLink fieldCode="AU" term="%22de+Almeida+Brehm+Pinhatti+F%22">de Almeida Brehm Pinhatti F</searchLink>; Laboratório de Patologia Experimental, PPGCS, Pontifícia Universidade Católica do Paraná, Curitiba, 80215-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Elifio-Esposito+S%22">Elifio-Esposito S</searchLink>; Laboratório de Patologia Experimental, PPGCS, Pontifícia Universidade Católica do Paraná, Curitiba, 80215-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Nicholls+W%22">Nicholls W</searchLink>; Queensland Children's Hospital, Brisbane, QLD, 4101, Australia.<br /><searchLink fieldCode="AU" term="%22de+Noronha+L%22">de Noronha L</searchLink>; Laboratório de Patologia Experimental, PPGCS, Pontifícia Universidade Católica do Paraná, Curitiba, 80215-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Kulasinghe+A%22">Kulasinghe A</searchLink>; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Souza-Fonseca-Guimaraes+F%22">Souza-Fonseca-Guimaraes F</searchLink>; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland (UQ), Woolloongabba, QLD, 4102, Australia. f.guimaraes@uq.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101475844%22">Genome medicine</searchLink> [Genome Med] 2026 Mar 31; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 Mar 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101475844 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-994X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221756994X%22">1756994X </searchLink><i>NLM ISO Abbreviation: </i>Genome Med <i>Subsets: </i>MEDLINE
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