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Simvastatin and Moxifloxacin Co-Delivery via ZIF-8/PDA Coating on PEEK Implants: A Strategy for Combating Implant-Associated Infection and Enhancing Osseointegration.

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Title: Simvastatin and Moxifloxacin Co-Delivery via ZIF-8/PDA Coating on PEEK Implants: A Strategy for Combating Implant-Associated Infection and Enhancing Osseointegration.
Authors: Wu Z; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China., Ma K; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.; State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China., Wu Z; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China., Guo X; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China., Qu Y; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China., Zhu Z; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China., Zhu W; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.; Department of Spinal Surgery, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi, People's Republic of China., Li C; State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China., Liu Y; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.; State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China., Ma R; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China., Yang P; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.
Source: International journal of nanomedicine [Int J Nanomedicine] 2026 Mar 25; Vol. 21, pp. 586499. Date of Electronic Publication: 2026 Mar 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Simvastatin and Moxifloxacin Co-Delivery via ZIF-8/PDA Coating on PEEK Implants: A Strategy for Combating Implant-Associated Infection and Enhancing Osseointegration.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ma+K%22">Ma K</searchLink>; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.; State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Qu+Y%22">Qu Y</searchLink>; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhu+W%22">Zhu W</searchLink>; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.; Department of Spinal Surgery, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.; State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ma+R%22">Ma R</searchLink>; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yang+P%22">Yang P</searchLink>; Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.
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      – TitleFull: Simvastatin and Moxifloxacin Co-Delivery via ZIF-8/PDA Coating on PEEK Implants: A Strategy for Combating Implant-Associated Infection and Enhancing Osseointegration.
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              Text: 2026 Mar 25
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