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Comparative effectiveness of anti-CD20 therapies and S1P receptor modulators in late-onset multiple sclerosis: real-world evidence from the MSBase registry.

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Title: Comparative effectiveness of anti-CD20 therapies and S1P receptor modulators in late-onset multiple sclerosis: real-world evidence from the MSBase registry.
Authors: Surcinelli A; Department of Neuroscience, Multiple Sclerosis Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Viale Vincenzo Randi 5, Ravenna 48121, Italy., Kalincik T; Neuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia.; CORe, Department of Medicine, University of Melbourne, Melbourne, Australia., Roos I; Neuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia.; CORe, Department of Medicine, University of Melbourne, Melbourne, Australia., D'Amico E; Università di Foggia, Medical and Surgical Sciences, Foggia, Italy., Lechner-Scott J; University Newcastle, Newcastle, Australia.; Hunter New England Health, John Hunter Hospital, NSW Australia., Ozakbas S; Izmir University of Economics, Medical Point Hospital, Izmir, Turkey.; Multiple Sclerosis Research Association, Izmir Turkey., Hradilek P; Department of Neurology, University Hospital Ostrava, Ostrava, Czech Republic., Horáková D; Charles University in Prague and General University Hospital, Prague, Czech Republic., Vachova M; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.; Department of Neurology, KZ a.s., Hospital Teplice, Teplice, Czech Republic., Panzera I; Department of Neuroscience, Multiple Sclerosis Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy., Ruzza S; Department of Neuroscience, Multiple Sclerosis Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy., Piscaglia MG; Department of Neuroscience, Multiple Sclerosis Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy., Gerlach O; Academic MS Center Zuyd, Department of Neurology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands.; School for Mental Health and Neuroscience, Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands., Meca-Lallana JE; Multiple Sclerosis CSUR and Clinical Neuroimmunology Unit, Neurology Department, Virgen de la Arrixaca Clinical University Hospital (IMIB-Arrixaca) and NICEM Cathedra-UCAM-San Antonio Catholic University, Murcia, Spain.; NICEM Cathedra. UCAM-San Antonio Catholic University, Murcia, Spain., Valero-López G; Multiple Sclerosis CSUR and Clinical Neuroimmunology Unit, Neurology Department, Virgen de la Arrixaca Clinical University Hospital (IMIB-Arrixaca) and NICEM Cathedra-UCAM-San Antonio Catholic University, Murcia, Spain.; NICEM Cathedra. UCAM-San Antonio Catholic University, Murcia, Spain., Kermode AG; Perron Institute for Neurological and Translational Science, Sir Charles Gairdner Hospital, QEIIMC, University of Western Australia, Nedlands, Australia.; Personalised Medicine Centre, Health Futures Institute, Murdoch University, Western Australia.; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia., Fabis-Pedrini MJ; Perron Institute for Neurological and Translational Science, Sir Charles Gairdner Hospital, QEIIMC, University of Western Australia, Nedlands, Australia.; Personalised Medicine Centre, Health Futures Institute, Murdoch University, Western Australia., Prevost J; CSSS Saint-Jérôme, Saint-Jerome, Canada., Ampapa R; Nemocnice Jihlava, Jihlava, Czech Republic., Hodgkinson S; Liverpool Hospital and UNSW and Ingham Institute Liverpool, Australia., Grand'Maison F; Neuro Rive-Sud, Quebec, Canada., Khoury SJ; American University of Beirut Medical Center, Beirut, Lebanon., John NA; Monash University, Clayton, Australia.; Department of Neurology, Monash Health, Clayton, Australia., Peterka M; Department of Neurology, Faculty of Medicine in Pilsen, Charles University and University Hospital Pilsen, Pilsen, Czech Republic.; Faculty of Medicine in Hradec Kralove, Charles University and University Hospital Hradec Kralove, Hradec Kralove, Czechia., Houskova J; Department of Neurology, Hospital Ceske Budejovice, Ceske Budejovice, Czech Republic., Recmanova E; Department of Neurology, Tomas Bata Regional Hospital, Zlin, Czech Republic., Rous Z; Department of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic., Shaygannejad V; Isfahan University of Medical Sciences(IUMS), Isfahan Neurosciences Research Center (INRC), Iran., Alroughani R; Amiri Hospital, Sharq, Kuwait., Kuhle J; University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland., Jakob GB; Department of Neurology, University Medical Centre Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Slovenia., Grammond P; CISSS Chaudière-Appalache, Levis, Canada., Patti F; Department of Medical and Surgical Sciences and Advanced Technologies, GF Ingrassia, Catania, Italy.; Multiple Sclerosis Unit, AOU Policlinico G Rodolico-San Marco, University of Catania, Catania, Italy., Van der Walt A; Department of Neurology, The Alfred Hospital, Melbourne, Australia.; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia., Butzkueven H; Department of Neurology, The Alfred Hospital, Melbourne, Australia.; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia., Foschi M; Department of Neuroscience, Multiple Sclerosis Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Source: Therapeutic advances in neurological disorders [Ther Adv Neurol Disord] 2026 Mar 26; Vol. 19, pp. 17562864261430084. Date of Electronic Publication: 2026 Mar 26 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: SAGE Country of Publication: England NLM ID: 101480242 Publication Model: eCollection Cited Medium: Print ISSN: 1756-2856 (Print) Linking ISSN: 17562856 NLM ISO Abbreviation: Ther Adv Neurol Disord Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Comparative effectiveness of anti-CD20 therapies and S1P receptor modulators in late-onset multiple sclerosis: real-world evidence from the MSBase registry.
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  Data: <searchLink fieldCode="AU" term="%22Surcinelli+A%22">Surcinelli A</searchLink>; Department of Neuroscience, Multiple Sclerosis Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Viale Vincenzo Randi 5, Ravenna 48121, Italy.<br /><searchLink fieldCode="AU" term="%22Kalincik+T%22">Kalincik T</searchLink>; Neuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia.; CORe, Department of Medicine, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Roos+I%22">Roos I</searchLink>; Neuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia.; CORe, Department of Medicine, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22D'Amico+E%22">D'Amico E</searchLink>; Università di Foggia, Medical and Surgical Sciences, Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Lechner-Scott+J%22">Lechner-Scott J</searchLink>; University Newcastle, Newcastle, Australia.; Hunter New England Health, John Hunter Hospital, NSW Australia.<br /><searchLink fieldCode="AU" term="%22Ozakbas+S%22">Ozakbas S</searchLink>; Izmir University of Economics, Medical Point Hospital, Izmir, Turkey.; Multiple Sclerosis Research Association, Izmir Turkey.<br /><searchLink fieldCode="AU" term="%22Hradilek+P%22">Hradilek P</searchLink>; Department of Neurology, University Hospital Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Horáková+D%22">Horáková D</searchLink>; Charles University in Prague and General University Hospital, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Vachova+M%22">Vachova M</searchLink>; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.; Department of Neurology, KZ a.s., Hospital Teplice, Teplice, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Panzera+I%22">Panzera I</searchLink>; Department of Neuroscience, Multiple Sclerosis Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy.<br /><searchLink fieldCode="AU" term="%22Ruzza+S%22">Ruzza S</searchLink>; Department of Neuroscience, Multiple Sclerosis Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy.<br /><searchLink fieldCode="AU" term="%22Piscaglia+MG%22">Piscaglia MG</searchLink>; Department of Neuroscience, Multiple Sclerosis Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy.<br /><searchLink fieldCode="AU" term="%22Gerlach+O%22">Gerlach O</searchLink>; Academic MS Center Zuyd, Department of Neurology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands.; School for Mental Health and Neuroscience, Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Meca-Lallana+JE%22">Meca-Lallana JE</searchLink>; Multiple Sclerosis CSUR and Clinical Neuroimmunology Unit, Neurology Department, Virgen de la Arrixaca Clinical University Hospital (IMIB-Arrixaca) and NICEM Cathedra-UCAM-San Antonio Catholic University, Murcia, Spain.; NICEM Cathedra. UCAM-San Antonio Catholic University, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Valero-López+G%22">Valero-López G</searchLink>; Multiple Sclerosis CSUR and Clinical Neuroimmunology Unit, Neurology Department, Virgen de la Arrixaca Clinical University Hospital (IMIB-Arrixaca) and NICEM Cathedra-UCAM-San Antonio Catholic University, Murcia, Spain.; NICEM Cathedra. UCAM-San Antonio Catholic University, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Kermode+AG%22">Kermode AG</searchLink>; Perron Institute for Neurological and Translational Science, Sir Charles Gairdner Hospital, QEIIMC, University of Western Australia, Nedlands, Australia.; Personalised Medicine Centre, Health Futures Institute, Murdoch University, Western Australia.; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Fabis-Pedrini+MJ%22">Fabis-Pedrini MJ</searchLink>; Perron Institute for Neurological and Translational Science, Sir Charles Gairdner Hospital, QEIIMC, University of Western Australia, Nedlands, Australia.; Personalised Medicine Centre, Health Futures Institute, Murdoch University, Western Australia.<br /><searchLink fieldCode="AU" term="%22Prevost+J%22">Prevost J</searchLink>; CSSS Saint-Jérôme, Saint-Jerome, Canada.<br /><searchLink fieldCode="AU" term="%22Ampapa+R%22">Ampapa R</searchLink>; Nemocnice Jihlava, Jihlava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hodgkinson+S%22">Hodgkinson S</searchLink>; Liverpool Hospital and UNSW and Ingham Institute Liverpool, Australia.<br /><searchLink fieldCode="AU" term="%22Grand'Maison+F%22">Grand'Maison F</searchLink>; Neuro Rive-Sud, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Khoury+SJ%22">Khoury SJ</searchLink>; American University of Beirut Medical Center, Beirut, Lebanon.<br /><searchLink fieldCode="AU" term="%22John+NA%22">John NA</searchLink>; Monash University, Clayton, Australia.; Department of Neurology, Monash Health, Clayton, Australia.<br /><searchLink fieldCode="AU" term="%22Peterka+M%22">Peterka M</searchLink>; Department of Neurology, Faculty of Medicine in Pilsen, Charles University and University Hospital Pilsen, Pilsen, Czech Republic.; Faculty of Medicine in Hradec Kralove, Charles University and University Hospital Hradec Kralove, Hradec Kralove, Czechia.<br /><searchLink fieldCode="AU" term="%22Houskova+J%22">Houskova J</searchLink>; Department of Neurology, Hospital Ceske Budejovice, Ceske Budejovice, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Recmanova+E%22">Recmanova E</searchLink>; Department of Neurology, Tomas Bata Regional Hospital, Zlin, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Rous+Z%22">Rous Z</searchLink>; Department of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Shaygannejad+V%22">Shaygannejad V</searchLink>; Isfahan University of Medical Sciences(IUMS), Isfahan Neurosciences Research Center (INRC), Iran.<br /><searchLink fieldCode="AU" term="%22Alroughani+R%22">Alroughani R</searchLink>; Amiri Hospital, Sharq, Kuwait.<br /><searchLink fieldCode="AU" term="%22Kuhle+J%22">Kuhle J</searchLink>; University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jakob+GB%22">Jakob GB</searchLink>; Department of Neurology, University Medical Centre Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Grammond+P%22">Grammond P</searchLink>; CISSS Chaudière-Appalache, Levis, Canada.<br /><searchLink fieldCode="AU" term="%22Patti+F%22">Patti F</searchLink>; Department of Medical and Surgical Sciences and Advanced Technologies, GF Ingrassia, Catania, Italy.; Multiple Sclerosis Unit, AOU Policlinico G Rodolico-San Marco, University of Catania, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Van+der+Walt+A%22">Van der Walt A</searchLink>; Department of Neurology, The Alfred Hospital, Melbourne, Australia.; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Butzkueven+H%22">Butzkueven H</searchLink>; Department of Neurology, The Alfred Hospital, Melbourne, Australia.; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Foschi+M%22">Foschi M</searchLink>; Department of Neuroscience, Multiple Sclerosis Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
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