TGF-β Pathway-Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method.

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Title: TGF-β Pathway-Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method.
Authors: Sanchez Mendez J; Department of Population and Public Health Sciences and USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California., Queme B; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California., Fu Y; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California., Morrison JL; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California., Lewinger JP; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California., Kawaguchi ES; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California., Mi H; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California., Obón-Santacana M; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain.; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain., Moratalla-Navarro F; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain.; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain., Martín V; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; The Research Group in Gene - Environment and Health Interactions (GIIGAS)/Institut of Biomedicine (IBIOMED), Universidad de León, León, Spain.; Faculty of Health Sciences, Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Universidad de León, León, Spain., Moreno V; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain.; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain., Qu C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington., Huyghe JR; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington., Newcomb PA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington., Phipps AI; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington., Thomas CE; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington., Conti DV; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California., Wang J; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California., Platz EA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Visvanathan K; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Keku TO; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina., Newton CC; Department of Population Science, American Cancer Society, Atlanta, Georgia., Um CY; Department of Population Science, American Cancer Society, Atlanta, Georgia., Kundaje A; Department of Genetics, Stanford University, Stanford, California.; Department of Computer Science, Stanford University, Stanford, California., Gunter MJ; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Dimou N; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France., Papadimitriou N; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., van Duijnhoven FJB; Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands., Männistö S; Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland., Rennert G; Association for Promotion in Research in Precision Medicine, Jerusalem, Israel.; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Wolk A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Hoffmeister M; Division of Clinical Epidemiology of Cancer Early Detection, German Cancer Research Center (DKFZ), Heidelberg, Germany., Brenner H; Cancer Prevention Graduate School, German Cancer Research Center (DKFZ), Heidelberg, Germany., Tian Y; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; School of Public Health, Capital Medical University, Beijing, China., Le Marchand L; University of Hawaii Cancer Center, Honolulu, Hawaii., Bouras E; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Tsilidis KK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Bishop DT; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom., Maclnnis RJ; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville Australia.; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, Australia., Ulrich CM; Huntsman Cancer Institute , University of Utah, Salt Lake City, Utah.; Department of Population Health Sciences, University of Utah, Salt Lake City, Utah., Peoples AR; Huntsman Cancer Institute , University of Utah, Salt Lake City, Utah.; Department of Population Health Sciences, University of Utah, Salt Lake City, Utah., Pellatt A; Internmountain Health, Salt Lake City, Utah., Li L; Department of Family Medicine, University of Virginia, Charlottesville, Virginia., Devall MA; Department of Family Medicine, University of Virginia, Charlottesville, Virginia., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Gruber SB; Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, California., Ruiz-Narvaez E; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan., Song M; Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.; Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Drew DA; Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Chan AT; Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.; Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts., Giannakis M; Broad Institute of Harvard and MIT, Cambridge, Massachusetts.; Dana-Farber Cancer Institute , Harvard Medical School, Harvard University, Boston, Massachusetts., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Department of Biostatistics, University of Washington, Seattle, Washington., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington., Stern MC; Department of Population and Public Health Sciences and USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California., Gauderman WJ; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2026 Jun 02; Vol. 35 (6), pp. 973-986.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9200608 Publication Model: Print Cited Medium: Internet ISSN: 1538-7755 (Electronic) Linking ISSN: 10559965 NLM ISO Abbreviation: Cancer Epidemiol Biomarkers Prev Subsets: MEDLINE
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  Data: TGF-β Pathway-Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method.
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University of Hawaii Cancer Center, Honolulu, Hawaii.<br /><searchLink fieldCode="AU" term="%22Bouras+E%22">Bouras E</searchLink>; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tsilidis+KK%22">Tsilidis KK</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bishop+DT%22">Bishop DT</searchLink>; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Maclnnis+RJ%22">Maclnnis RJ</searchLink>; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Buchanan+DD%22">Buchanan DD</searchLink>; 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Chan School of Public Health, Harvard University, Boston, Massachusetts.; Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts.; Department of Immunology and Infectious Diseases, Harvard T.H. 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      – TitleFull: TGF-β Pathway-Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method.
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          Dates:
            – D: 02
              M: 06
              Text: 2026 Jun 02
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1538-7755
          Numbering:
            – Type: volume
              Value: 35
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
              Type: main
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