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Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt.

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Title: Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt.
Authors: Prallet S; Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany., Maier N; Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany., Li A; Institute for Pharmacy and Molecular Biotechnology, Heidelberg University and BioQuant, Heidelberg, Germany., Afting C; Centre for Organismal Studies Heidelberg (COS), Heidelberg University, Germany., Huang HE; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany., Hu J; Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany., Toprak E; Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany., Keya DP; Child Health Research Foundation, Dhaka, Bangladesh., Colasanti O; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany., León-Janampa N; INSERM U1259 MAVIVHe, Université de Tours et CHRU de Tours, Tours, France., Marlet J; INSERM U1259 MAVIVHe, Université de Tours et CHRU de Tours, Tours, France., Beisel C; Department of Infectious Diseases and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany., Mogler C; Institute of Pathology, School of Medicine and Health, Technical University Munich, Munich, Germany., Puchas P; Department of Gastroenterology, Hepatology, Infectious Diseases and Intoxications, Heidelberg University Hospital, Heidelberg, Germany., Behrendt P; TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between Helmholtz - Centre for Infection Research and Hannover Medical School, Hannover, Germany., Boettler T; Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany., Steinmann E; Department for Molecular and Medical Virology, Faculty of Medicine, Ruhr University Bochum, Bochum, Germany.; German Centre for Infection Research, External Partner Site, Bochum, Germany., Saha S; Child Health Research Foundation, Dhaka, Bangladesh., Laketa V; German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany.; Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany., Lohmann V; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.; German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany., Wittbrodt J; Institute for Pharmacy and Molecular Biotechnology, Heidelberg University and BioQuant, Heidelberg, Germany., Hermann C; Institute for Pharmacy and Molecular Biotechnology, Heidelberg University and BioQuant, Heidelberg, Germany., Dill MT; Department of Gastroenterology, Hepatology, Infectious Diseases and Intoxications, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ) Heidelberg, Experimental Hepatology, Inflammation and Cancer, Heidelberg, Germany., Dao Thi VL; Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.; German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany.
Source: Science advances [Sci Adv] 2026 Apr 03; Vol. 12 (14), pp. eaeb2333. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt.
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  Data: <searchLink fieldCode="AU" term="%22Prallet+S%22">Prallet S</searchLink>; Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Maier+N%22">Maier N</searchLink>; Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Li+A%22">Li A</searchLink>; Institute for Pharmacy and Molecular Biotechnology, Heidelberg University and BioQuant, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Afting+C%22">Afting C</searchLink>; Centre for Organismal Studies Heidelberg (COS), Heidelberg University, Germany.<br /><searchLink fieldCode="AU" term="%22Huang+HE%22">Huang HE</searchLink>; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Toprak+E%22">Toprak E</searchLink>; Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Keya+DP%22">Keya DP</searchLink>; Child Health Research Foundation, Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Colasanti+O%22">Colasanti O</searchLink>; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22León-Janampa+N%22">León-Janampa N</searchLink>; INSERM U1259 MAVIVHe, Université de Tours et CHRU de Tours, Tours, France.<br /><searchLink fieldCode="AU" term="%22Marlet+J%22">Marlet J</searchLink>; INSERM U1259 MAVIVHe, Université de Tours et CHRU de Tours, Tours, France.<br /><searchLink fieldCode="AU" term="%22Beisel+C%22">Beisel C</searchLink>; Department of Infectious Diseases and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mogler+C%22">Mogler C</searchLink>; Institute of Pathology, School of Medicine and Health, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Puchas+P%22">Puchas P</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Intoxications, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Behrendt+P%22">Behrendt P</searchLink>; TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between Helmholtz - Centre for Infection Research and Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Boettler+T%22">Boettler T</searchLink>; Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Steinmann+E%22">Steinmann E</searchLink>; Department for Molecular and Medical Virology, Faculty of Medicine, Ruhr University Bochum, Bochum, Germany.; German Centre for Infection Research, External Partner Site, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Saha+S%22">Saha S</searchLink>; Child Health Research Foundation, Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Laketa+V%22">Laketa V</searchLink>; German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany.; Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lohmann+V%22">Lohmann V</searchLink>; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.; German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wittbrodt+J%22">Wittbrodt J</searchLink>; Institute for Pharmacy and Molecular Biotechnology, Heidelberg University and BioQuant, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hermann+C%22">Hermann C</searchLink>; Institute for Pharmacy and Molecular Biotechnology, Heidelberg University and BioQuant, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dill+MT%22">Dill MT</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Intoxications, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ) Heidelberg, Experimental Hepatology, Inflammation and Cancer, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dao+Thi+VL%22">Dao Thi VL</searchLink>; Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.; German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany.
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