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Direct Oral Challenge for Penicillin Allergy: The International Network of Antibiotic Allergy Nations (iNAAN) Study.

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Title: Direct Oral Challenge for Penicillin Allergy: The International Network of Antibiotic Allergy Nations (iNAAN) Study.
Authors: Mitri EA; Department of Infectious Diseases and Immunology, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; National Allergy Centre of Excellence, Parkville, Victoria, Australia., Fletcher LR; Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia.; Department of Critical Care, University of Melbourne, Melbourne, Victoria, Australia.; Data Analytics Research and Evaluation Centre, Austin Health, Heidelberg, Victoria, Australia., Vogrin S; Department of Infectious Diseases and Immunology, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Barnes S; Monash Lung Sleep Allergy and Immunology, Monash Health, Clayton, Victoria, Australia.; Department of Medicine, Monash University, Clayton, Victoria, Australia., Powell N; Pharmacy Department, Royal Cornwall Hospitals NHS Trust, Truro, United Kingdom., Peter J; Allergy and Immunology Unit, University of Cape Town Lung Institute, Mowbray, Cape Town, South Africa.; Division of Allergology and Clinical Immunology, Department of Medicine, Faculty of Health Sciences, Groote Schuur Hospital, Observatory, Cape Town, South Africa., Li PH; Division of Rheumatology and Clinical Immunology, Department of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong., Copaescu AM; Department of Infectious Diseases and Immunology, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada., Turner NA; Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA., James F; Department of Infectious Diseases and Immunology, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Paynter C; School of Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia., Sullivan R; Department of Infectious Diseases, School of Clinical Medicine, St George Hospital, UNSW Medicine and Health, Kogarah, NSW, Australia., Masoum MS; Department of Pharmacy and Department of Infectious Diseases, Royal Perth Hospital, Perth, Western Australia, Australia., Rawlins M; Department of Pharmacy, Fiona Stanley Hospital, Perth, Western Australia, Australia., Mackay G; Department of Pharmacy, Albury Wodonga Health, Albury, New South Wales, Australia., Smith BJ; Department of Infectious Diseases, Western Health, Footscray, Victoria, Australia., Kilfoyle P; Pharmacy Department, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.; Faculty of Medicine, School of Public Health, University of Queensland, Brisbane, Queensland, Australia., Forster D; Department of Infectious Diseases, Eastern Health, Box Hill, Victoria, Australia., Rose M; Department of Infectious Diseases and Immunology, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Cowan R; Internal Medical Services, Grampians Health Service, Ballarat, Victoria, Australia., Alcorn K; Department of Infectious Diseases, Gold Coast Hospital and Health Service, Gold Coast, Queensland, Australia.; School of Medicine, Griffith University, Gold Coast, Queensland, Australia., Brischetto A; Infectious Diseases Unit, Redcliffe Hospital,Brisbane, Queensland, Australia., Mahony A; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Infectious Diseases Unit, Bendigo Health, Bendigo, Victoria, Australia.; Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia., Redmond A; Infectious Diseases Unit, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland, Australia.; School of Medicine, University of Queensland, Brisbane, Queensland, Australia., Chakravorty A; Infectious Diseases and General Medicine, St John of God Subiaco, Perth, Western Australia, Australia., Meher-Homji Z; Department of Medicine, Latrobe Regional Health, Traralgon, Victoria, Australia.; School of Rural Health, Monash University, Gippsland, Victoria, Australia., Yuson C; Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, South Australia, Australia., Crawford S; Department of Infectious Diseases, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; School of Medicine, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Weeks G; Pharmacy Department, Barwon Health, Geelong, Victoria, Australia., Ponnampalavanar SSS; Infectious Disease Unit, Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur50603, Malaysia.; Department of Infection Control, Universiti Malaya Medical Centre, Kuala Lumpur 50603, Malaysia., Katelaris C; Immunology/Allergy Unit, Department of Medicine, Campbelltown Hospital and Western Sydney University, Sydney, New South Wales, Australia., Tran P; Department of Pharmacy, Campbelltown Hospital, Sydney, New South Wales, Australia., O'Hern J; Department of Infectious Diseases, Launceston General Hospital, Launceston, Tasmania, Australia., Godsell J; Department of Infectious Diseases and Immunology, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.; Department of Clinical Immunology and Allergy, The Royal Melbourne Hospital, Melbourne, Victoria, Australia., Peel TN; Department of Infectious Diseases, The Alfred Hospital and School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Sandaradura I; Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales, Australia.; Sydney Infectious Diseases Institute, University of Sydney, Sydney, New South Wales, Australia.; Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Sydney, New South Wales, Australia., New D; Department of Infectious Diseases, Armadale Health Service, Perth, Western Australia, Australia., Holland C; Department of Infectious Diseases, Ipswich Hospital, Ipswich, Queensland, Australia.; Metro North Public Health Unit,Windsor, Queensland, Australia.; School of Public Health, University of Queensland, Herston, Queensland, Australia., Cutfield T; Department of Infectious Diseases, Middlemore Hospital, Auckland, New Zealand., Coghill S; Department of Infectious Diseases, Lismore Base Hospital, Lismore, New South Wales, Australia., Hand C; Pharmacy Department, Mildura Base Public Hospital, Mildura, Victoria, Australia., Williams J; Department of Infectious Diseases, Orange Health Service, Orange, New South Wales, Australia.; School of Rural Health, Charles Sturt University, Orange, New South Wales, Australia., Bishop J; Development and Improvement, East Grampians Health Service, Ararat, Victoria, Australia., Lambros B; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.; The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Department of Nursing, School of Health Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia., Day C; Allergy and Immunology Unit, University of Cape Town Lung Institute, Mowbray, Cape Town, South Africa.; Division of Allergology and Clinical Immunology, Department of Medicine, Faculty of Health Sciences, Groote Schuur Hospital, Observatory, Cape Town, South Africa., Ierano C; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Department of Infectious Diseases, National Centre for Antimicrobial Stewardship, University of Melbourne, Melbourne, Victoria, Australia., Roberts JA; University of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.; Herston Infectious Diseases Institute, Metro North Health, Brisbane, Queensland, Australia.; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.; UR UM 103, Division of Anesthesia Critical Care and Emergency and Pain Medicine, University of Montpellier, Nimes University Hospital, Nimes, France., Holmes NE; Department of Infectious Diseases and Immunology, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Klaic M; School of Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia., Fernando SL; Department of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Trubiano JA; Department of Infectious Diseases and Immunology, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; National Allergy Centre of Excellence, Parkville, Victoria, Australia.
Corporate Authors: International Network of Antibiotic Allergy Nations (iNAAN) Study Group
Source: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2026 Jul 08; Vol. 82 (6), pp. e1148-e1162.
Publication Type: Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE
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  Data: Direct Oral Challenge for Penicillin Allergy: The International Network of Antibiotic Allergy Nations (iNAAN) Study.
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Department of Infectious Diseases and Immunology, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Turner+NA%22">Turner NA</searchLink>; Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22James+F%22">James F</searchLink>; Department of Infectious Diseases and Immunology, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Paynter+C%22">Paynter C</searchLink>; 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          Dates:
            – D: 08
              M: 07
              Text: 2026 Jul 08
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1537-6591
          Numbering:
            – Type: volume
              Value: 82
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
              Type: main
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