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Optimization of Covalent 6-Cyanoquinazoline KRASG12C Inhibitors for the Treatment of Solid Tumors.

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Bibliographic Details
Title: Optimization of Covalent 6-Cyanoquinazoline KRASG12C Inhibitors for the Treatment of Solid Tumors.
Authors: Waldo JP; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Krawczuk PJ; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Kelly CB; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Callas CG; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Cisar JS; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Eccles W; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Guerrero CA; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Hack MD; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States., Jones WM; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Keohane CE; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Li LS; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Meegalla S; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Padilla-Salinas R; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Rosano RJ; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Shimkin KW; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Simonnet YRF; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Sitkoff D; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Sookezian A; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Winters MP; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Bush TL; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Cheung ST; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Del Rosario AM; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Hansen R; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Janes MR; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Janjua H; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Kazmi F; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Kirkpatrick R; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., La D; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States., Lenhart R; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Lorenzi MV; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Liu Y; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Mesens N; Johnson & Johnson, Turnhoutseweg 30, Beerse 2340, Belgium., Milligan CM; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Murrey H; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Peters U; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Ren P; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Richter M; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Rizzolio M; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States., Rao S; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Shaffer P; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Stratton CF; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Szewczuk LM; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Wen J; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Wong V; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Yanovich C; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Laquerre S; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Edwards JP; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States., Leonard KA; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9163-9195. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.5c03610