View in EDS

Optimization of Covalent 6-Cyanoquinazoline KRASG12C Inhibitors for the Treatment of Solid Tumors.

Saved in:
Bibliographic Details
Title: Optimization of Covalent 6-Cyanoquinazoline KRASG12C Inhibitors for the Treatment of Solid Tumors.
Authors: Waldo JP; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Krawczuk PJ; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Kelly CB; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Callas CG; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Cisar JS; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Eccles W; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Guerrero CA; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Hack MD; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States., Jones WM; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Keohane CE; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Li LS; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Meegalla S; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Padilla-Salinas R; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Rosano RJ; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Shimkin KW; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Simonnet YRF; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Sitkoff D; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Sookezian A; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Winters MP; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Bush TL; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Cheung ST; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Del Rosario AM; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Hansen R; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Janes MR; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Janjua H; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Kazmi F; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Kirkpatrick R; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., La D; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States., Lenhart R; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Lorenzi MV; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Liu Y; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Mesens N; Johnson & Johnson, Turnhoutseweg 30, Beerse 2340, Belgium., Milligan CM; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Murrey H; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Peters U; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Ren P; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Richter M; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Rizzolio M; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States., Rao S; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Shaffer P; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Stratton CF; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Szewczuk LM; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Wen J; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States., Wong V; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Yanovich C; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Laquerre S; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Edwards JP; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States., Leonard KA; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9163-9195. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41921095
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Optimization of Covalent 6-Cyanoquinazoline KRAS<superscript>G12C</superscript> Inhibitors for the Treatment of Solid Tumors.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Waldo+JP%22">Waldo JP</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Krawczuk+PJ%22">Krawczuk PJ</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+CB%22">Kelly CB</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Callas+CG%22">Callas CG</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Cisar+JS%22">Cisar JS</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Eccles+W%22">Eccles W</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Guerrero+CA%22">Guerrero CA</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Hack+MD%22">Hack MD</searchLink>; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Jones+WM%22">Jones WM</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Keohane+CE%22">Keohane CE</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Li+LS%22">Li LS</searchLink>; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Meegalla+S%22">Meegalla S</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Padilla-Salinas+R%22">Padilla-Salinas R</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Rosano+RJ%22">Rosano RJ</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Shimkin+KW%22">Shimkin KW</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Simonnet+YRF%22">Simonnet YRF</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Sitkoff+D%22">Sitkoff D</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Sookezian+A%22">Sookezian A</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Winters+MP%22">Winters MP</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Bush+TL%22">Bush TL</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Cheung+ST%22">Cheung ST</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Del+Rosario+AM%22">Del Rosario AM</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Hansen+R%22">Hansen R</searchLink>; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Janes+MR%22">Janes MR</searchLink>; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Janjua+H%22">Janjua H</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Kazmi+F%22">Kazmi F</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Kirkpatrick+R%22">Kirkpatrick R</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22La+D%22">La D</searchLink>; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Lenhart+R%22">Lenhart R</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Lorenzi+MV%22">Lorenzi MV</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Mesens+N%22">Mesens N</searchLink>; Johnson & Johnson, Turnhoutseweg 30, Beerse 2340, Belgium.<br /><searchLink fieldCode="AU" term="%22Milligan+CM%22">Milligan CM</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Murrey+H%22">Murrey H</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Peters+U%22">Peters U</searchLink>; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Ren+P%22">Ren P</searchLink>; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Richter+M%22">Richter M</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Rizzolio+M%22">Rizzolio M</searchLink>; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Rao+S%22">Rao S</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Shaffer+P%22">Shaffer P</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Stratton+CF%22">Stratton CF</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Szewczuk+LM%22">Szewczuk LM</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Wen+J%22">Wen J</searchLink>; Wellspring Biosciences, Inc., 3033 Science Park Road, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Wong+V%22">Wong V</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Yanovich+C%22">Yanovich C</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Laquerre+S%22">Laquerre S</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Edwards+JP%22">Edwards JP</searchLink>; Johnson & Johnson, 3210 Merryfield Row, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Leonard+KA%22">Leonard KA</searchLink>; Johnson & Johnson, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9163-9195. <i>Date of Electronic Publication: </i>2026 Apr 01.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41921095
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.5c03610
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 9163
    Titles:
      – TitleFull: Optimization of Covalent 6-Cyanoquinazoline KRASG12C Inhibitors for the Treatment of Solid Tumors.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Waldo JP
      – PersonEntity:
          Name:
            NameFull: Krawczuk PJ
      – PersonEntity:
          Name:
            NameFull: Kelly CB
      – PersonEntity:
          Name:
            NameFull: Callas CG
      – PersonEntity:
          Name:
            NameFull: Cisar JS
      – PersonEntity:
          Name:
            NameFull: Eccles W
      – PersonEntity:
          Name:
            NameFull: Guerrero CA
      – PersonEntity:
          Name:
            NameFull: Hack MD
      – PersonEntity:
          Name:
            NameFull: Jones WM
      – PersonEntity:
          Name:
            NameFull: Keohane CE
      – PersonEntity:
          Name:
            NameFull: Li LS
      – PersonEntity:
          Name:
            NameFull: Meegalla S
      – PersonEntity:
          Name:
            NameFull: Padilla-Salinas R
      – PersonEntity:
          Name:
            NameFull: Rosano RJ
      – PersonEntity:
          Name:
            NameFull: Shimkin KW
      – PersonEntity:
          Name:
            NameFull: Simonnet YRF
      – PersonEntity:
          Name:
            NameFull: Sitkoff D
      – PersonEntity:
          Name:
            NameFull: Sookezian A
      – PersonEntity:
          Name:
            NameFull: Winters MP
      – PersonEntity:
          Name:
            NameFull: Bush TL
      – PersonEntity:
          Name:
            NameFull: Cheung ST
      – PersonEntity:
          Name:
            NameFull: Del Rosario AM
      – PersonEntity:
          Name:
            NameFull: Hansen R
      – PersonEntity:
          Name:
            NameFull: Janes MR
      – PersonEntity:
          Name:
            NameFull: Janjua H
      – PersonEntity:
          Name:
            NameFull: Kazmi F
      – PersonEntity:
          Name:
            NameFull: Kirkpatrick R
      – PersonEntity:
          Name:
            NameFull: La D
      – PersonEntity:
          Name:
            NameFull: Lenhart R
      – PersonEntity:
          Name:
            NameFull: Lorenzi MV
      – PersonEntity:
          Name:
            NameFull: Liu Y
      – PersonEntity:
          Name:
            NameFull: Mesens N
      – PersonEntity:
          Name:
            NameFull: Milligan CM
      – PersonEntity:
          Name:
            NameFull: Murrey H
      – PersonEntity:
          Name:
            NameFull: Peters U
      – PersonEntity:
          Name:
            NameFull: Ren P
      – PersonEntity:
          Name:
            NameFull: Richter M
      – PersonEntity:
          Name:
            NameFull: Rizzolio M
      – PersonEntity:
          Name:
            NameFull: Rao S
      – PersonEntity:
          Name:
            NameFull: Shaffer P
      – PersonEntity:
          Name:
            NameFull: Stratton CF
      – PersonEntity:
          Name:
            NameFull: Szewczuk LM
      – PersonEntity:
          Name:
            NameFull: Wen J
      – PersonEntity:
          Name:
            NameFull: Wong V
      – PersonEntity:
          Name:
            NameFull: Yanovich C
      – PersonEntity:
          Name:
            NameFull: Laquerre S
      – PersonEntity:
          Name:
            NameFull: Edwards JP
      – PersonEntity:
          Name:
            NameFull: Leonard KA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 23
              M: 04
              Text: 2026 Apr 23
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 69
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1