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Denosumab is associated with longer real-world progression-free survival in BRCA1/2-mutated HR+ /HER2 - breast cancer patients with bone metastases receiving CDK4/6 inhibitors: A multicenter Italian study.

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Title: Denosumab is associated with longer real-world progression-free survival in BRCA1/2-mutated HR+ /HER2 - breast cancer patients with bone metastases receiving CDK4/6 inhibitors: A multicenter Italian study.
Authors: Scafetta R; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Troiano R; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Gullotta C; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Guarino A; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Fiore C; Medical Oncology Unit, Santa Rosa Hospital, Department of Oncology and Hematology, Strada Sammartinese snc, Viterbo 01100, Italy., Sisca L; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Speziale E; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Donato M; Division of Medical Oncology, 'G.Martino' University Hospital, Via Consolare Valeria 1, Messina 98124, Italy., Foderaro S; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy., Venuti F; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Vilardi FA; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Ricozzi V; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy., Iuliani M; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy. Electronic address: m.iuliani@policlinicocampus.it., Simonetti S; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Cavaliere S; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Cortellini A; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy., Cesa A; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy., Botticelli A; Department of Radiological, Oncological and Pathological Science, 'Sapienza' University of Rome, Rome, Italy., Scagnoli S; Department of Radiological, Oncological and Pathological Science, 'Sapienza' University of Rome, Rome, Italy., Pisegna S; Department of Experimental Medicine Sapienza University, Rome, Italy; Medical Oncology Unit, Azienda Ospedaliero Universitaria Sant'Andrea, Via Di Grottaross, Rome 1035-1039, Italy., Criscitiello C; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy., Pedersini R; Medical Oncology Department, ASST Spedali Civili of Brescia, Brescia, Italy., Sposetti C; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy; Dana-Farber/Partners CancerCare, Boston, MA, USA; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Tiberi E; Department of Medical Oncology, Università Politecnica delle Marche, AOU delle Marche, Ancona, Italy., D'Auria G; Department of Medical Oncology, Medical Oncology Unit, Sandro Pertini Hospital, Rome, Italy., Vergati M; Department of Medical Oncology, Medical Oncology Unit, Sandro Pertini Hospital, Rome, Italy., Mazzotta M; Department of Medical Oncology, Medical Oncology Unit, Sandro Pertini Hospital, Rome, Italy., Caputo R; Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Pascale, Naples, Italy., Verrazzo A; Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Pascale, Naples, Italy., Garrone O; Medical Oncology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy., Domati F; Department of Oncology and Hematology, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy., Piombino C; Department of Oncology and Hematology, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy., Lisa FSD; UOSD Sperimentazioni di fase IV - IRCCS Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, Roma 00144, Italy., Filomeno L; UOSD Sperimentazioni di fase IV - IRCCS Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, Roma 00144, Italy., Arcuri T; UOSD Sperimentazioni di fase IV - IRCCS Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, Roma 00144, Italy., Puce F; Medical Oncology Unit, ICS Maugeri IRCCS, Pavia, Italy., Riva F; Department of Clinical and Molecular Medicine, 'La Sapienza' University of Rome, Policlinico Umberto I, Viale Regina Elena 324, Rome 00161, Italy., Palleschi M; Medical Oncology, Breast & GYN Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Sirico M; Medical Oncology, Breast & GYN Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Piras M; Department of Medical Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Stucci LS; Interdisciplinary Department of Medicine, University of Bari 'A. Moro' and Division of Medical Oncology, A.O.U. Consorziale Policlinico di Bari, Bari, Italy., Lisi D; Medical Oncology Unit, Santa Chiara Hospital, APSS Trento, Italy., Orsaria P; Department of Breast Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Grasso A; Department of Breast Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Ippolito E; Department of Radiation Oncology (Medicine and Surgery), Università Campus Bio-Medico di Roma, Rome, Italy; Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Ramella S; Department of Radiation Oncology (Medicine and Surgery), Università Campus Bio-Medico di Roma, Rome, Italy; Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Visani L; Radiation Oncology Unit & Breast Unit, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy., Livi L; Radiation Oncology Unit & Breast Unit, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy., Gori S; Medical Oncology, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella (VR), Italy., Rossi L; UOC of Oncology - ASL Latina - Distretto 1, University of Rome 'Sapienza', Formia, Italy., Meattini I; Radiation Oncology Unit & Breast Unit, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Department of Radiation Oncology (MAASTRO), GROW Research Institute for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands., Tagliaferri B; Medical Oncology Unit, ICS Maugeri IRCCS, Pavia, Italy., Caffo O; Medical Oncology Unit, Santa Chiara Hospital, APSS Trento, Italy; Center of Medical Science - University of Trento, Italy., Bonomo MV; Medical Oncology Unit, Policlinico Universitario Tor Vergata, Rome, Italy., Portarena I; Medical Oncology Unit, Policlinico Universitario Tor Vergata, Rome, Italy., Irelli A; Medical Oncology Unit, Department of Oncology, 'Giuseppe Mazzini' Hospital, AUSL 04 Teramo, Teramo 64100, Italy., Cretella E; Medical Oncology Unit, Ospedale di Bolzano, Bolzano, Italy., Porta C; Interdisciplinary Department of Medicine, University of Bari 'A. Moro' and Division of Medical Oncology, A.O.U. Consorziale Policlinico di Bari, Bari, Italy., Bianchini G; Department of Medical Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy; Università Vita-Salute San Raffaele, Milano, Italy., Fabbri MA; Medical Oncology Unit, Santa Rosa Hospital, Department of Oncology and Hematology, Strada Sammartinese snc, Viterbo 01100, Italy., Giorgi U; Department of Experimental Medicine, University of Salento, Lecce, Italy., Vici P; UOSD Sperimentazioni di fase IV - IRCCS Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, Roma 00144, Italy., Toss A; Department of Oncology and Hematology, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy; Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Italy., Ruatta F; Medical Oncology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy., Laurentiis M; Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Pascale, Naples, Italy., Villa F; Medical Oncology, Oncology Department ASST Lecco, Lecco 23900, Italy., Berardi R; Department of Medical Oncology, Università Politecnica delle Marche, AOU delle Marche, Ancona, Italy., Minelli M; UOC Oncologia Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy., Altomare V; Department of Breast Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Vernieri C; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Curigliano G; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy; European Institute of Oncology, IRCCS, Milano, Italy., Chirco A; ASST Papa Giovanni XXIII-SC Oncologia, Bergamo 24127, Italy., D'Alessandro S; ASST Papa Giovanni XXIII-SC Oncologia, Bergamo 24127, Italy., Vincenzi B; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy., Tonini G; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy., Santini D; Dip. Scienze e Biotecnologie Medico-chirurgiche, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Pantano F; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 May 15; Vol. 239, pp. 116703. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
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AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Denosumab is associated with longer real-world progression-free survival in BRCA1/2-mutated HR+ /HER2 - breast cancer patients with bone metastases receiving CDK4/6 inhibitors: A multicenter Italian study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Scafetta+R%22">Scafetta R</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Troiano+R%22">Troiano R</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Gullotta+C%22">Gullotta C</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Guarino+A%22">Guarino A</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Fiore+C%22">Fiore C</searchLink>; Medical Oncology Unit, Santa Rosa Hospital, Department of Oncology and Hematology, Strada Sammartinese snc, Viterbo 01100, Italy.<br /><searchLink fieldCode="AU" term="%22Sisca+L%22">Sisca L</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Speziale+E%22">Speziale E</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Donato+M%22">Donato M</searchLink>; Division of Medical Oncology, 'G.Martino' University Hospital, Via Consolare Valeria 1, Messina 98124, Italy.<br /><searchLink fieldCode="AU" term="%22Foderaro+S%22">Foderaro S</searchLink>; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Venuti+F%22">Venuti F</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Vilardi+FA%22">Vilardi FA</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Ricozzi+V%22">Ricozzi V</searchLink>; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Iuliani+M%22">Iuliani M</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy. Electronic address: m.iuliani@policlinicocampus.it.<br /><searchLink fieldCode="AU" term="%22Simonetti+S%22">Simonetti S</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Cavaliere+S%22">Cavaliere S</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Cortellini+A%22">Cortellini A</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Cesa+A%22">Cesa A</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Botticelli+A%22">Botticelli A</searchLink>; Department of Radiological, Oncological and Pathological Science, 'Sapienza' University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Scagnoli+S%22">Scagnoli S</searchLink>; Department of Radiological, Oncological and Pathological Science, 'Sapienza' University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pisegna+S%22">Pisegna S</searchLink>; Department of Experimental Medicine Sapienza University, Rome, Italy; Medical Oncology Unit, Azienda Ospedaliero Universitaria Sant'Andrea, Via Di Grottaross, Rome 1035-1039, Italy.<br /><searchLink fieldCode="AU" term="%22Criscitiello+C%22">Criscitiello C</searchLink>; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Pedersini+R%22">Pedersini R</searchLink>; Medical Oncology Department, ASST Spedali Civili of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Sposetti+C%22">Sposetti C</searchLink>; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy; Dana-Farber/Partners CancerCare, Boston, MA, USA; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tiberi+E%22">Tiberi E</searchLink>; Department of Medical Oncology, Università Politecnica delle Marche, AOU delle Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22D'Auria+G%22">D'Auria G</searchLink>; Department of Medical Oncology, Medical Oncology Unit, Sandro Pertini Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vergati+M%22">Vergati M</searchLink>; Department of Medical Oncology, Medical Oncology Unit, Sandro Pertini Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mazzotta+M%22">Mazzotta M</searchLink>; Department of Medical Oncology, Medical Oncology Unit, Sandro Pertini Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Caputo+R%22">Caputo R</searchLink>; Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Pascale, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Verrazzo+A%22">Verrazzo A</searchLink>; Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Pascale, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Garrone+O%22">Garrone O</searchLink>; Medical Oncology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Domati+F%22">Domati F</searchLink>; Department of Oncology and Hematology, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Piombino+C%22">Piombino C</searchLink>; Department of Oncology and Hematology, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Lisa+FSD%22">Lisa FSD</searchLink>; UOSD Sperimentazioni di fase IV - IRCCS Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, Roma 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Filomeno+L%22">Filomeno L</searchLink>; UOSD Sperimentazioni di fase IV - IRCCS Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, Roma 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Arcuri+T%22">Arcuri T</searchLink>; UOSD Sperimentazioni di fase IV - IRCCS Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, Roma 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Puce+F%22">Puce F</searchLink>; Medical Oncology Unit, ICS Maugeri IRCCS, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Riva+F%22">Riva F</searchLink>; Department of Clinical and Molecular Medicine, 'La Sapienza' University of Rome, Policlinico Umberto I, Viale Regina Elena 324, Rome 00161, Italy.<br /><searchLink fieldCode="AU" term="%22Palleschi+M%22">Palleschi M</searchLink>; Medical Oncology, Breast & GYN Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Sirico+M%22">Sirico M</searchLink>; Medical Oncology, Breast & GYN Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Piras+M%22">Piras M</searchLink>; Department of Medical Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Stucci+LS%22">Stucci LS</searchLink>; Interdisciplinary Department of Medicine, University of Bari 'A. Moro' and Division of Medical Oncology, A.O.U. Consorziale Policlinico di Bari, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Lisi+D%22">Lisi D</searchLink>; Medical Oncology Unit, Santa Chiara Hospital, APSS Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Orsaria+P%22">Orsaria P</searchLink>; Department of Breast Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Grasso+A%22">Grasso A</searchLink>; Department of Breast Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ippolito+E%22">Ippolito E</searchLink>; Department of Radiation Oncology (Medicine and Surgery), Università Campus Bio-Medico di Roma, Rome, Italy; Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ramella+S%22">Ramella S</searchLink>; Department of Radiation Oncology (Medicine and Surgery), Università Campus Bio-Medico di Roma, Rome, Italy; Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Visani+L%22">Visani L</searchLink>; Radiation Oncology Unit & Breast Unit, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Livi+L%22">Livi L</searchLink>; Radiation Oncology Unit & Breast Unit, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Gori+S%22">Gori S</searchLink>; Medical Oncology, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella (VR), Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+L%22">Rossi L</searchLink>; UOC of Oncology - ASL Latina - Distretto 1, University of Rome 'Sapienza', Formia, Italy.<br /><searchLink fieldCode="AU" term="%22Meattini+I%22">Meattini I</searchLink>; Radiation Oncology Unit & Breast Unit, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Department of Radiation Oncology (MAASTRO), GROW Research Institute for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tagliaferri+B%22">Tagliaferri B</searchLink>; Medical Oncology Unit, ICS Maugeri IRCCS, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Caffo+O%22">Caffo O</searchLink>; Medical Oncology Unit, Santa Chiara Hospital, APSS Trento, Italy; Center of Medical Science - University of Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Bonomo+MV%22">Bonomo MV</searchLink>; Medical Oncology Unit, Policlinico Universitario Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Portarena+I%22">Portarena I</searchLink>; Medical Oncology Unit, Policlinico Universitario Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Irelli+A%22">Irelli A</searchLink>; Medical Oncology Unit, Department of Oncology, 'Giuseppe Mazzini' Hospital, AUSL 04 Teramo, Teramo 64100, Italy.<br /><searchLink fieldCode="AU" term="%22Cretella+E%22">Cretella E</searchLink>; Medical Oncology Unit, Ospedale di Bolzano, Bolzano, Italy.<br /><searchLink fieldCode="AU" term="%22Porta+C%22">Porta C</searchLink>; Interdisciplinary Department of Medicine, University of Bari 'A. Moro' and Division of Medical Oncology, A.O.U. Consorziale Policlinico di Bari, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Bianchini+G%22">Bianchini G</searchLink>; Department of Medical Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy; Università Vita-Salute San Raffaele, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Fabbri+MA%22">Fabbri MA</searchLink>; Medical Oncology Unit, Santa Rosa Hospital, Department of Oncology and Hematology, Strada Sammartinese snc, Viterbo 01100, Italy.<br /><searchLink fieldCode="AU" term="%22Giorgi+U%22">Giorgi U</searchLink>; Department of Experimental Medicine, University of Salento, Lecce, Italy.<br /><searchLink fieldCode="AU" term="%22Vici+P%22">Vici P</searchLink>; UOSD Sperimentazioni di fase IV - IRCCS Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, Roma 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Toss+A%22">Toss A</searchLink>; Department of Oncology and Hematology, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy; Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Ruatta+F%22">Ruatta F</searchLink>; Medical Oncology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Laurentiis+M%22">Laurentiis M</searchLink>; Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Pascale, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Villa+F%22">Villa F</searchLink>; Medical Oncology, Oncology Department ASST Lecco, Lecco 23900, Italy.<br /><searchLink fieldCode="AU" term="%22Berardi+R%22">Berardi R</searchLink>; Department of Medical Oncology, Università Politecnica delle Marche, AOU delle Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Minelli+M%22">Minelli M</searchLink>; UOC Oncologia Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Altomare+V%22">Altomare V</searchLink>; Department of Breast Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vernieri+C%22">Vernieri C</searchLink>; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Curigliano+G%22">Curigliano G</searchLink>; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy; European Institute of Oncology, IRCCS, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Chirco+A%22">Chirco A</searchLink>; ASST Papa Giovanni XXIII-SC Oncologia, Bergamo 24127, Italy.<br /><searchLink fieldCode="AU" term="%22D'Alessandro+S%22">D'Alessandro S</searchLink>; ASST Papa Giovanni XXIII-SC Oncologia, Bergamo 24127, Italy.<br /><searchLink fieldCode="AU" term="%22Vincenzi+B%22">Vincenzi B</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Tonini+G%22">Tonini G</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Santini+D%22">Santini D</searchLink>; Dip. Scienze e Biotecnologie Medico-chirurgiche, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pantano+F%22">Pantano F</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Roma 00128, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, Roma 00128, Italy.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 May 15; Vol. 239, pp. 116703. <i>Date of Electronic Publication: </i>2026 Mar 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9005373 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0852 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209598049%22">09598049 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Cancer <i>Subsets: </i>MEDLINE
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      – TitleFull: Denosumab is associated with longer real-world progression-free survival in BRCA1/2-mutated HR+ /HER2 - breast cancer patients with bone metastases receiving CDK4/6 inhibitors: A multicenter Italian study.
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