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Long-term outcomes after nucleos(t)ide analogue cessation in chronic hepatitis B - follow-up from the RETRACT-B cohort.

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Title: Long-term outcomes after nucleos(t)ide analogue cessation in chronic hepatitis B - follow-up from the RETRACT-B cohort.
Authors: Dongelmans E; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Hirode G; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada; The Toronto Viral Hepatitis Care Network (VIRCAN), Toronto, Canada., van Bӧmmel F; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany., Jeng WJ; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Taoyuan City, Taiwan., Chien RN; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Taoyuan City, Taiwan., Chen CH; Department of Gastroenterology and Hepatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan., Kilany M; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada; The Toronto Viral Hepatitis Care Network (VIRCAN), Toronto, Canada., Su TH; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan., Kao JH; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan., Seto WK; Department of Medicine and State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong Special Administrative Region of China., Liang LY; Medical Data Analytics Centre (MDAC), The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China., Reikvam DH; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Holmberg M; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Infectious Diseases, Vestfold Hospital, Tønsberg, Norway., Furquim d'Almeida A; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium; Viral Hepatitis Research Group, Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium., Papatheodoridi M; 1st Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Maasoumy B; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany., Hansen B; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada., Post R; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands., Pocurull A; Liver Unit, Hospital Clinic Barcelona, IDIBAPS and CIBEREHD, University of Barcelona, Barcelona, Spain., Terrault N; Gastrointestinal and Liver Diseases Division, Keck School of Medicine of University of Southern California, Los Angeles, California, USA., Ghany M; Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA., Johannessen A; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Infectious Diseases, Vestfold Hospital, Tønsberg, Norway., Lok A; Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA., Vanwolleghem T; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium; Viral Hepatitis Research Group, Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium., Lens S; Liver Unit, Hospital Clinic Barcelona, IDIBAPS and CIBEREHD, University of Barcelona, Barcelona, Spain., Cornberg M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany; Centre for Individualised Infection Medicine (CiiM), A Joint Venture of Helmholtz Centre for Infection Research and Hannover Medical School, Hannover, Germany., Yuen MF; Department of Medicine and State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong Special Administrative Region of China., Wong G; Medical Data Analytics Centre (MDAC), The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China., Sonneveld M; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Papatheodoridis G; 1st Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Berg T; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany., Hsu YC; Department of Medical Research, School of Medicine, E-Da Hospital/I-Shou University, Kaohsiung City, Taiwan., Feld J; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada; The Toronto Viral Hepatitis Care Network (VIRCAN), Toronto, Canada., Janssen H; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada. Electronic address: h.janssen@erasmusmc.nl.
Corporate Authors: RETRACT-B study group
Source: Journal of hepatology [J Hepatol] 2026 Jul; Vol. 85 (1), pp. 61-70. Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Long-term outcomes after nucleos(t)ide analogue cessation in chronic hepatitis B - follow-up from the RETRACT-B cohort.
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  Data: <searchLink fieldCode="AU" term="%22Dongelmans+E%22">Dongelmans E</searchLink>; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hirode+G%22">Hirode G</searchLink>; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada; The Toronto Viral Hepatitis Care Network (VIRCAN), Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22van+Bӧmmel+F%22">van Bӧmmel F</searchLink>; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Jeng+WJ%22">Jeng WJ</searchLink>; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chien+RN%22">Chien RN</searchLink>; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Department of Gastroenterology and Hepatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kilany+M%22">Kilany M</searchLink>; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada; The Toronto Viral Hepatitis Care Network (VIRCAN), Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Su+TH%22">Su TH</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+JH%22">Kao JH</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Seto+WK%22">Seto WK</searchLink>; Department of Medicine and State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Liang+LY%22">Liang LY</searchLink>; Medical Data Analytics Centre (MDAC), The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Reikvam+DH%22">Reikvam DH</searchLink>; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Holmberg+M%22">Holmberg M</searchLink>; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Infectious Diseases, Vestfold Hospital, Tønsberg, Norway.<br /><searchLink fieldCode="AU" term="%22Furquim+d'Almeida+A%22">Furquim d'Almeida A</searchLink>; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium; Viral Hepatitis Research Group, Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Papatheodoridi+M%22">Papatheodoridi M</searchLink>; 1st Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Maasoumy+B%22">Maasoumy B</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hansen+B%22">Hansen B</searchLink>; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Post+R%22">Post R</searchLink>; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pocurull+A%22">Pocurull A</searchLink>; Liver Unit, Hospital Clinic Barcelona, IDIBAPS and CIBEREHD, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Terrault+N%22">Terrault N</searchLink>; Gastrointestinal and Liver Diseases Division, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Ghany+M%22">Ghany M</searchLink>; Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Johannessen+A%22">Johannessen A</searchLink>; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Infectious Diseases, Vestfold Hospital, Tønsberg, Norway.<br /><searchLink fieldCode="AU" term="%22Lok+A%22">Lok A</searchLink>; Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Vanwolleghem+T%22">Vanwolleghem T</searchLink>; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium; Viral Hepatitis Research Group, Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Lens+S%22">Lens S</searchLink>; Liver Unit, Hospital Clinic Barcelona, IDIBAPS and CIBEREHD, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cornberg+M%22">Cornberg M</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany; Centre for Individualised Infection Medicine (CiiM), A Joint Venture of Helmholtz Centre for Infection Research and Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Yuen+MF%22">Yuen MF</searchLink>; Department of Medicine and State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Wong+G%22">Wong G</searchLink>; Medical Data Analytics Centre (MDAC), The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Sonneveld+M%22">Sonneveld M</searchLink>; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Papatheodoridis+G%22">Papatheodoridis G</searchLink>; 1st Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Berg+T%22">Berg T</searchLink>; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Hsu+YC%22">Hsu YC</searchLink>; Department of Medical Research, School of Medicine, E-Da Hospital/I-Shou University, Kaohsiung City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Feld+J%22">Feld J</searchLink>; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada; The Toronto Viral Hepatitis Care Network (VIRCAN), Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Janssen+H%22">Janssen H</searchLink>; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada. Electronic address: h.janssen@erasmusmc.nl.
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