Single-cell profiling of BAL in preschool cystic fibrosis reveals macrophage dysregulation and ivacaftor-modified inflammatory programs in the early life lung.
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| Title: | Single-cell profiling of BAL in preschool cystic fibrosis reveals macrophage dysregulation and ivacaftor-modified inflammatory programs in the early life lung. |
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| Authors: | Maksimovic J; Computational Biology Program, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia., Shanthikumar S; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia; Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, VIC, Australia., Howitt G; Computational Biology Program, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia., Dixit G; Computational Biology Program, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia., Hickey PF; Cellular Genomics Projects Team, Advanced Technology and Biology Division, WEHI, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Anttila C; Cellular Genomics Projects Team, Advanced Technology and Biology Division, WEHI, Parkville, VIC, Australia., Brown DV; Cellular Genomics Projects Team, Advanced Technology and Biology Division, WEHI, Parkville, VIC, Australia., Gubbels L; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, VIC, Australia., Senabouth A; Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, NSW, Australia; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, NSW, Australia., Amann-Zalcenstein D; Cellular Genomics Projects Team, Advanced Technology and Biology Division, WEHI, Parkville, VIC, Australia., Powell JE; Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, NSW, Australia; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, NSW, Australia., Ranganathan SC; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia; Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, VIC, Australia., Oshlack A; Computational Biology Program, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia; School of Mathematics and Statistics, University of Melbourne, Parkville, VIC, Australia., Neeland MR; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. Electronic address: melanie.neeland@mcri.edu.au. |
| Source: | Mucosal immunology [Mucosal Immunol] 2026 Jun; Vol. 19 (3), pp. 100338. Date of Electronic Publication: 2026 Mar 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 101299742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-3456 (Electronic) Linking ISSN: 19330219 NLM ISO Abbreviation: Mucosal Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41921915 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Single-cell profiling of BAL in preschool cystic fibrosis reveals macrophage dysregulation and ivacaftor-modified inflammatory programs in the early life lung. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Maksimovic+J%22">Maksimovic J</searchLink>; Computational Biology Program, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Shanthikumar+S%22">Shanthikumar S</searchLink>; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia; Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Howitt+G%22">Howitt G</searchLink>; Computational Biology Program, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dixit+G%22">Dixit G</searchLink>; Computational Biology Program, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hickey+PF%22">Hickey PF</searchLink>; Cellular Genomics Projects Team, Advanced Technology and Biology Division, WEHI, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Anttila+C%22">Anttila C</searchLink>; Cellular Genomics Projects Team, Advanced Technology and Biology Division, WEHI, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Brown+DV%22">Brown DV</searchLink>; Cellular Genomics Projects Team, Advanced Technology and Biology Division, WEHI, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Gubbels+L%22">Gubbels L</searchLink>; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Senabouth+A%22">Senabouth A</searchLink>; Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, NSW, Australia; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Amann-Zalcenstein+D%22">Amann-Zalcenstein D</searchLink>; Cellular Genomics Projects Team, Advanced Technology and Biology Division, WEHI, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Powell+JE%22">Powell JE</searchLink>; Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, NSW, Australia; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ranganathan+SC%22">Ranganathan SC</searchLink>; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia; Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Oshlack+A%22">Oshlack A</searchLink>; Computational Biology Program, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia; School of Mathematics and Statistics, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Neeland+MR%22">Neeland MR</searchLink>; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. Electronic address: melanie.neeland@mcri.edu.au. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101299742%22">Mucosal immunology</searchLink> [Mucosal Immunol] 2026 Jun; Vol. 19 (3), pp. 100338. <i>Date of Electronic Publication: </i>2026 Mar 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101299742 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1935-3456 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219330219%22">19330219 </searchLink><i>NLM ISO Abbreviation: </i>Mucosal Immunol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41921915 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.mucimm.2026.03.012 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 100338 Titles: – TitleFull: Single-cell profiling of BAL in preschool cystic fibrosis reveals macrophage dysregulation and ivacaftor-modified inflammatory programs in the early life lung. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Maksimovic J – PersonEntity: Name: NameFull: Shanthikumar S – PersonEntity: Name: NameFull: Howitt G – PersonEntity: Name: NameFull: Dixit G – PersonEntity: Name: NameFull: Hickey PF – PersonEntity: Name: NameFull: Anttila C – PersonEntity: Name: NameFull: Brown DV – PersonEntity: Name: NameFull: Gubbels L – PersonEntity: Name: NameFull: Senabouth A – PersonEntity: Name: NameFull: Amann-Zalcenstein D – PersonEntity: Name: NameFull: Powell JE – PersonEntity: Name: NameFull: Ranganathan SC – PersonEntity: Name: NameFull: Oshlack A – PersonEntity: Name: NameFull: Neeland MR IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1935-3456 Numbering: – Type: volume Value: 19 – Type: issue Value: 3 Titles: – TitleFull: Mucosal immunology Type: main |
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