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Stiff matrix-induced KRTAP2-3 expression suppresses ciliogenesis via actin tension-driven chromatin remodeling.

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Title: Stiff matrix-induced KRTAP2-3 expression suppresses ciliogenesis via actin tension-driven chromatin remodeling.
Authors: Chen X; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Yi L; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Xie G; Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China., Jin H; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Yang F; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Cao W; State Key Laboratory of Industrial Control Technology, Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, Zhejiang University, Hangzhou, China., Shi Z; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China., Xu Z; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Li S; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Huo C; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Li Y; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Lin A; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, China., Liu W; Metabolic Medicine Center, International Institutes of Medicine and the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China., Ou G; Tsinghua-Peking Center for Life Sciences, Ministry of Education Key Laboratory for Protein Science, School of Life Sciences, Tsinghua University, Beijing, China., Zhou T; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. tzhou@zju.edu.cn.; Center for RNA Medicine, International Institutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China. tzhou@zju.edu.cn., Ji B; Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou, China. bhji@zju.edu.cn.; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. bhji@zju.edu.cn., Xie S; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China. sxie@zju.edu.cn.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. sxie@zju.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2026 Apr 02; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Stiff matrix-induced KRTAP2-3 expression suppresses ciliogenesis via actin tension-driven chromatin remodeling.
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  Data: <searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yi+L%22">Yi L</searchLink>; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xie+G%22">Xie G</searchLink>; Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Jin+H%22">Jin H</searchLink>; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+F%22">Yang F</searchLink>; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cao+W%22">Cao W</searchLink>; State Key Laboratory of Industrial Control Technology, Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Huo+C%22">Huo C</searchLink>; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+A%22">Lin A</searchLink>; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+W%22">Liu W</searchLink>; Metabolic Medicine Center, International Institutes of Medicine and the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.<br /><searchLink fieldCode="AU" term="%22Ou+G%22">Ou G</searchLink>; Tsinghua-Peking Center for Life Sciences, Ministry of Education Key Laboratory for Protein Science, School of Life Sciences, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+T%22">Zhou T</searchLink>; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. tzhou@zju.edu.cn.; Center for RNA Medicine, International Institutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China. tzhou@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ji+B%22">Ji B</searchLink>; Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou, China. bhji@zju.edu.cn.; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. bhji@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xie+S%22">Xie S</searchLink>; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China. sxie@zju.edu.cn.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. sxie@zju.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Apr 02; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Apr 02.
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        Text: English
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