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Patient-derived intestinal organoids as a model for site-specific mucosal bacterial interactions in paediatric inflammatory bowel disease.

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Title: Patient-derived intestinal organoids as a model for site-specific mucosal bacterial interactions in paediatric inflammatory bowel disease.
Authors: Chan E; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia., Chan WH; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia., Kerr G; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia., Archer SK; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.; Monash Genomics and Bioinformatics Platform, Monash University, Clayton, VIC, 3800, Australia., Jardé T; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia., Engel RM; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.; Department of Surgery, Cabrini Hospital, Cabrini Monash University, Malvern, VIC, 3144, Australia., Gould JA; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia., Amarasinghe SL; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia., Rutten EL; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia., D'Adamo GL; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia., Gulliver EL; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia., Gearing LJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia., Forster SC; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia. sam.forster@hudson.org.au.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia. sam.forster@hudson.org.au., Giles EM; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia. edward.giles@monash.edu.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia. edward.giles@monash.edu.; Department of Paediatrics, Monash University, Clayton, VIC, 3800, Australia. edward.giles@monash.edu., Abud HE; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia. helen.abud@monash.edu.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia. helen.abud@monash.edu.; Department of Surgery, Cabrini Hospital, Cabrini Monash University, Malvern, VIC, 3144, Australia. helen.abud@monash.edu.
Source: Scientific reports [Sci Rep] 2026 Apr 01; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Patient-derived intestinal organoids as a model for site-specific mucosal bacterial interactions in paediatric inflammatory bowel disease.
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  Data: <searchLink fieldCode="AU" term="%22Chan+E%22">Chan E</searchLink>; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Chan+WH%22">Chan WH</searchLink>; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Kerr+G%22">Kerr G</searchLink>; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Archer+SK%22">Archer SK</searchLink>; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.; Monash Genomics and Bioinformatics Platform, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Jardé+T%22">Jardé T</searchLink>; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Engel+RM%22">Engel RM</searchLink>; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.; Department of Surgery, Cabrini Hospital, Cabrini Monash University, Malvern, VIC, 3144, Australia.<br /><searchLink fieldCode="AU" term="%22Gould+JA%22">Gould JA</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Amarasinghe+SL%22">Amarasinghe SL</searchLink>; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Rutten+EL%22">Rutten EL</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22D'Adamo+GL%22">D'Adamo GL</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Gulliver+EL%22">Gulliver EL</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Gearing+LJ%22">Gearing LJ</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Forster+SC%22">Forster SC</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia. sam.forster@hudson.org.au.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia. sam.forster@hudson.org.au.<br /><searchLink fieldCode="AU" term="%22Giles+EM%22">Giles EM</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia. edward.giles@monash.edu.; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3800, Australia. edward.giles@monash.edu.; Department of Paediatrics, Monash University, Clayton, VIC, 3800, Australia. edward.giles@monash.edu.<br /><searchLink fieldCode="AU" term="%22Abud+HE%22">Abud HE</searchLink>; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia. helen.abud@monash.edu.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia. helen.abud@monash.edu.; Department of Surgery, Cabrini Hospital, Cabrini Monash University, Malvern, VIC, 3144, Australia. helen.abud@monash.edu.
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