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ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas.

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Title: ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas.
Authors: Hennequart M; The Francis Crick Institute, London, UK. marc.hennequart@unamur.be.; NARILIS Institute, UNamur, Namur, Belgium. marc.hennequart@unamur.be., Mervant L; The Francis Crick Institute, London, UK., Stockis J; University of Cambridge, CRUK Cambridge Institute, Cambridge, UK.; de Duve Institute, UCLouvain, Brussels, Belgium., Coomes J; The Francis Crick Institute, London, UK., Zarou MM; The Francis Crick Institute, London, UK., Gerard L; NARILIS Institute, UNamur, Namur, Belgium., Tevel V; NARILIS Institute, UNamur, Namur, Belgium., Migeot V; NARILIS Institute, UNamur, Namur, Belgium., Pilley SE; The Francis Crick Institute, London, UK.; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Lee Y; The Francis Crick Institute, London, UK., Driscoll PC; The Francis Crick Institute, London, UK., Legrave NM; The Francis Crick Institute, London, UK.; Luxembourg institute of Health, Luxembourg, Luxembourg., Labuschagne CF; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University Potchefstroom, Potchefstroom, South Africa., Zani F; The Francis Crick Institute, London, UK.; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada., Uribe AH; School of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK., Ferreira RMM; The Francis Crick Institute, London, UK., Cheung EC; The Francis Crick Institute, London, UK., Malanchi I; The Francis Crick Institute, London, UK., MacRae JI; The Francis Crick Institute, London, UK., Maddocks ODK; School of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK., Halim TYF; University of Cambridge, CRUK Cambridge Institute, Cambridge, UK., Vousden KH; The Francis Crick Institute, London, UK. karen.vousden@crick.ac.uk.
Source: Nature metabolism [Nat Metab] 2026 Apr; Vol. 8 (4), pp. 810-823. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hennequart+M%22">Hennequart M</searchLink>; The Francis Crick Institute, London, UK. marc.hennequart@unamur.be.; NARILIS Institute, UNamur, Namur, Belgium. marc.hennequart@unamur.be.<br /><searchLink fieldCode="AU" term="%22Mervant+L%22">Mervant L</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Stockis+J%22">Stockis J</searchLink>; University of Cambridge, CRUK Cambridge Institute, Cambridge, UK.; de Duve Institute, UCLouvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Coomes+J%22">Coomes J</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Zarou+MM%22">Zarou MM</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Gerard+L%22">Gerard L</searchLink>; NARILIS Institute, UNamur, Namur, Belgium.<br /><searchLink fieldCode="AU" term="%22Tevel+V%22">Tevel V</searchLink>; NARILIS Institute, UNamur, Namur, Belgium.<br /><searchLink fieldCode="AU" term="%22Migeot+V%22">Migeot V</searchLink>; NARILIS Institute, UNamur, Namur, Belgium.<br /><searchLink fieldCode="AU" term="%22Pilley+SE%22">Pilley SE</searchLink>; The Francis Crick Institute, London, UK.; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Driscoll+PC%22">Driscoll PC</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Legrave+NM%22">Legrave NM</searchLink>; The Francis Crick Institute, London, UK.; Luxembourg institute of Health, Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Labuschagne+CF%22">Labuschagne CF</searchLink>; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University Potchefstroom, Potchefstroom, South Africa.<br /><searchLink fieldCode="AU" term="%22Zani+F%22">Zani F</searchLink>; The Francis Crick Institute, London, UK.; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Uribe+AH%22">Uribe AH</searchLink>; School of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Ferreira+RMM%22">Ferreira RMM</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Cheung+EC%22">Cheung EC</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Malanchi+I%22">Malanchi I</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22MacRae+JI%22">MacRae JI</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Maddocks+ODK%22">Maddocks ODK</searchLink>; School of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Halim+TYF%22">Halim TYF</searchLink>; University of Cambridge, CRUK Cambridge Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vousden+KH%22">Vousden KH</searchLink>; The Francis Crick Institute, London, UK. karen.vousden@crick.ac.uk.
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