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Pharmacokinetics of Landiolol and Its Metabolite M1 During Renal Replacement Therapy in Septic Shock Patients: A Sub-Study of the Landi-SEP Trial.

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Title: Pharmacokinetics of Landiolol and Its Metabolite M1 During Renal Replacement Therapy in Septic Shock Patients: A Sub-Study of the Landi-SEP Trial.
Authors: Rehberg S; Department of Anaesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine and Pain Therapy, University Hospital of Bielefeld, Campus Bielefeld-Bethel, Protestant Hospital of the Bethel Foundation, Burgsteig 13, 33617, Bielefeld, Germany., Borgstedt R; Department of Anaesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine and Pain Therapy, University Hospital of Bielefeld, Campus Bielefeld-Bethel, Protestant Hospital of the Bethel Foundation, Burgsteig 13, 33617, Bielefeld, Germany., Frank S; Department of Anaesthesiology, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany., Černý V; Department of Anaesthesiology, Perioperative Medicine and Intensive Care, Masaryk Hospital, Sociální péče 3316 /12A401 13, Ústí nad Labem, Czech Republic.; Department of Anaesthesia and Intensive Care, 3rd Medical Faculty and University Hospital Královské Vinohrady, Charles University, Šrobárova 50, 100 34, Prague 10, Czech Republic.; Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Canada.; Faculty of Social Sciences and Health Care, Constantine the Philospher University in Nitra, Nitra, Slovakia., Sus J; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria. jan.sus@aop-health.com., Unger M; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria., Klade C; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria., Krejcy K; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria., Kirchbaumer-Baroian N; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria., Bouvet O; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria., Krumpl G; AOP Health International Management AG, Industriering 20, 9491, Ruggell, Liechtenstein., Duška F; Department of Anaesthesia and Intensive Care, 3rd Medical Faculty and University Hospital Královské Vinohrady, Charles University, Šrobárova 50, 100 34, Prague 10, Czech Republic.
Corporate Authors: LANDI-SEP Study Group
Source: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2026 May; Vol. 51 (3), pp. 305-314. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Springer France Country of Publication: France NLM ID: 7608491 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2107-0180 (Electronic) Linking ISSN: 03787966 NLM ISO Abbreviation: Eur J Drug Metab Pharmacokinet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacokinetics of Landiolol and Its Metabolite M1 During Renal Replacement Therapy in Septic Shock Patients: A Sub-Study of the Landi-SEP Trial.
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  Data: <searchLink fieldCode="AU" term="%22Rehberg+S%22">Rehberg S</searchLink>; Department of Anaesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine and Pain Therapy, University Hospital of Bielefeld, Campus Bielefeld-Bethel, Protestant Hospital of the Bethel Foundation, Burgsteig 13, 33617, Bielefeld, Germany.<br /><searchLink fieldCode="AU" term="%22Borgstedt+R%22">Borgstedt R</searchLink>; Department of Anaesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine and Pain Therapy, University Hospital of Bielefeld, Campus Bielefeld-Bethel, Protestant Hospital of the Bethel Foundation, Burgsteig 13, 33617, Bielefeld, Germany.<br /><searchLink fieldCode="AU" term="%22Frank+S%22">Frank S</searchLink>; Department of Anaesthesiology, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Černý+V%22">Černý V</searchLink>; Department of Anaesthesiology, Perioperative Medicine and Intensive Care, Masaryk Hospital, Sociální péče 3316 /12A401 13, Ústí nad Labem, Czech Republic.; Department of Anaesthesia and Intensive Care, 3rd Medical Faculty and University Hospital Královské Vinohrady, Charles University, Šrobárova 50, 100 34, Prague 10, Czech Republic.; Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Canada.; Faculty of Social Sciences and Health Care, Constantine the Philospher University in Nitra, Nitra, Slovakia.<br /><searchLink fieldCode="AU" term="%22Sus+J%22">Sus J</searchLink>; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria. jan.sus@aop-health.com.<br /><searchLink fieldCode="AU" term="%22Unger+M%22">Unger M</searchLink>; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Klade+C%22">Klade C</searchLink>; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Krejcy+K%22">Krejcy K</searchLink>; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kirchbaumer-Baroian+N%22">Kirchbaumer-Baroian N</searchLink>; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Bouvet+O%22">Bouvet O</searchLink>; AOP Orphan Pharmaceuticals GmbH, Leopold-Ungar-Platz 2, 1190, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Krumpl+G%22">Krumpl G</searchLink>; AOP Health International Management AG, Industriering 20, 9491, Ruggell, Liechtenstein.<br /><searchLink fieldCode="AU" term="%22Duška+F%22">Duška F</searchLink>; Department of Anaesthesia and Intensive Care, 3rd Medical Faculty and University Hospital Královské Vinohrady, Charles University, Šrobárova 50, 100 34, Prague 10, Czech Republic.
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