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MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy.

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Title: MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy.
Authors: Burr SP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Auckland K; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Glynos A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Dhawanjewar A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Ryall C; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Wei W; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Hynes-Allen A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Prater M; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Altos Labs Cambridge Institute, Cambridge, UK., Sczaniecka-Clift M; MRC Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK., Prudent J; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Chinnery PF; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. pfc25@cam.ac.uk.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. pfc25@cam.ac.uk., van den Ameele J; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. jv361@cam.ac.uk.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. jv361@cam.ac.uk.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2026 Apr; Vol. 33 (4), pp. 711-723. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Burr+SP%22">Burr SP</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Auckland+K%22">Auckland K</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Glynos+A%22">Glynos A</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dhawanjewar+A%22">Dhawanjewar A</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ryall+C%22">Ryall C</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wei+W%22">Wei W</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hynes-Allen+A%22">Hynes-Allen A</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Prater+M%22">Prater M</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Altos Labs Cambridge Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sczaniecka-Clift+M%22">Sczaniecka-Clift M</searchLink>; MRC Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Prudent+J%22">Prudent J</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Chinnery+PF%22">Chinnery PF</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. pfc25@cam.ac.uk.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. pfc25@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22van+den+Ameele+J%22">van den Ameele J</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. jv361@cam.ac.uk.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. jv361@cam.ac.uk.
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