MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy.
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| Title: | MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy. |
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| Authors: | Burr SP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Auckland K; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Glynos A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Dhawanjewar A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Ryall C; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Wei W; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Hynes-Allen A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Prater M; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Altos Labs Cambridge Institute, Cambridge, UK., Sczaniecka-Clift M; MRC Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK., Prudent J; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Chinnery PF; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. pfc25@cam.ac.uk.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. pfc25@cam.ac.uk., van den Ameele J; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. jv361@cam.ac.uk.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. jv361@cam.ac.uk. |
| Source: | Nature structural & molecular biology [Nat Struct Mol Biol] 2026 Apr; Vol. 33 (4), pp. 711-723. Date of Electronic Publication: 2026 Apr 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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