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The biased adenosine-rich content of the HIV-1 genome serves as a molecular signature that facilitates efficient packaging.

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Title: The biased adenosine-rich content of the HIV-1 genome serves as a molecular signature that facilitates efficient packaging.
Authors: Vuong HR; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Zhou Q; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., L Lesko S; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705., Tenneti K; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Davis K; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Scott S; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705., Guo M; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Boodwa-Ko D; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Eschbach JE; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Gopal K; Cell and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109., Porter JM; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Wang Q; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Xia M; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Boateng A; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Wang Y; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Mohammed S; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Lee N; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Telesnitsky A; Cell and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109.; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109., M Sherer N; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705., Kutluay SB; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 07; Vol. 123 (14), pp. e2522851123. Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Vuong+HR%22">Vuong HR</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Zhou+Q%22">Zhou Q</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22L+Lesko+S%22">L Lesko S</searchLink>; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705.<br /><searchLink fieldCode="AU" term="%22Tenneti+K%22">Tenneti K</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Davis+K%22">Davis K</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Scott+S%22">Scott S</searchLink>; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705.<br /><searchLink fieldCode="AU" term="%22Guo+M%22">Guo M</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Boodwa-Ko+D%22">Boodwa-Ko D</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Eschbach+JE%22">Eschbach JE</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Gopal+K%22">Gopal K</searchLink>; Cell and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109.<br /><searchLink fieldCode="AU" term="%22Porter+JM%22">Porter JM</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Xia+M%22">Xia M</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Boateng+A%22">Boateng A</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Mohammed+S%22">Mohammed S</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Lee+N%22">Lee N</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Telesnitsky+A%22">Telesnitsky A</searchLink>; Cell and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109.; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.<br /><searchLink fieldCode="AU" term="%22M+Sherer+N%22">M Sherer N</searchLink>; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705.<br /><searchLink fieldCode="AU" term="%22Kutluay+SB%22">Kutluay SB</searchLink>; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
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