Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis.
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| Title: | Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis. |
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| Authors: | Choi A; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea., Lee JY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Yoon H; Department of Biomedical Engineering, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, USA., Che X; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Institute for Translational Research in Dentistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea., Choi M; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea., Park Y; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Shin K; Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea., Lee H; Bio-MAX Institute, Seoul National University, Seoul, Republic of Korea.; Botnar Institute of Immune Engineering, Basel, Switzerland., Park J; Division of Endocrinology and Metabolism, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Kong SH; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Division of Endocrinology and Metabolism, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Kim J; Division of Data Science, College of Information and Communication Technology, The University of Suwon, Hwaseong, Republic of Korea., Lee AC; Meteor Biotech, Co. Ltd, Seoul, Republic of Korea., Shin CS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Division of Endocrinology and Metabolism, Seoul National University Hospital, Seoul, Republic of Korea., Choi JY; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Institute for Translational Research in Dentistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea., Lee J; Department of Biomedical Engineering, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, USA.; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.; Molecular & Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA., Kwon S; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea. skwon@snu.ac.kr.; Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea. skwon@snu.ac.kr.; Bio-MAX Institute, Seoul National University, Seoul, Republic of Korea. skwon@snu.ac.kr., Kim SW; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. swkimmd@snu.ac.kr.; Division of Endocrinology and Metabolism, Boramae Medical Center, Seoul, Republic of Korea. swkimmd@snu.ac.kr. |
| Source: | Bone research [Bone Res] 2026 Apr 02; Vol. 14 (1). Date of Electronic Publication: 2026 Apr 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2095-4700 |
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| DOI: | 10.1038/s41413-026-00521-9 |
