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Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis.

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Title: Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis.
Authors: Choi A; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea., Lee JY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Yoon H; Department of Biomedical Engineering, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, USA., Che X; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Institute for Translational Research in Dentistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea., Choi M; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea., Park Y; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Shin K; Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea., Lee H; Bio-MAX Institute, Seoul National University, Seoul, Republic of Korea.; Botnar Institute of Immune Engineering, Basel, Switzerland., Park J; Division of Endocrinology and Metabolism, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Kong SH; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Division of Endocrinology and Metabolism, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Kim J; Division of Data Science, College of Information and Communication Technology, The University of Suwon, Hwaseong, Republic of Korea., Lee AC; Meteor Biotech, Co. Ltd, Seoul, Republic of Korea., Shin CS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Division of Endocrinology and Metabolism, Seoul National University Hospital, Seoul, Republic of Korea., Choi JY; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Institute for Translational Research in Dentistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea., Lee J; Department of Biomedical Engineering, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, USA.; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.; Molecular & Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA., Kwon S; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea. skwon@snu.ac.kr.; Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea. skwon@snu.ac.kr.; Bio-MAX Institute, Seoul National University, Seoul, Republic of Korea. skwon@snu.ac.kr., Kim SW; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. swkimmd@snu.ac.kr.; Division of Endocrinology and Metabolism, Boramae Medical Center, Seoul, Republic of Korea. swkimmd@snu.ac.kr.
Source: Bone research [Bone Res] 2026 Apr 02; Vol. 14 (1). Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis.
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  Data: <searchLink fieldCode="AU" term="%22Choi+A%22">Choi A</searchLink>; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+H%22">Yoon H</searchLink>; Department of Biomedical Engineering, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, USA.<br /><searchLink fieldCode="AU" term="%22Che+X%22">Che X</searchLink>; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Institute for Translational Research in Dentistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+M%22">Choi M</searchLink>; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+Y%22">Park Y</searchLink>; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shin+K%22">Shin K</searchLink>; Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Bio-MAX Institute, Seoul National University, Seoul, Republic of Korea.; Botnar Institute of Immune Engineering, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Division of Endocrinology and Metabolism, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kong+SH%22">Kong SH</searchLink>; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Division of Endocrinology and Metabolism, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Division of Data Science, College of Information and Communication Technology, The University of Suwon, Hwaseong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+AC%22">Lee AC</searchLink>; Meteor Biotech, Co. Ltd, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Shin+CS%22">Shin CS</searchLink>; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Division of Endocrinology and Metabolism, Seoul National University Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+JY%22">Choi JY</searchLink>; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Institute for Translational Research in Dentistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Biomedical Engineering, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, USA.; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.; Molecular & Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kwon+S%22">Kwon S</searchLink>; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea. skwon@snu.ac.kr.; Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea. skwon@snu.ac.kr.; Bio-MAX Institute, Seoul National University, Seoul, Republic of Korea. skwon@snu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Kim+SW%22">Kim SW</searchLink>; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. swkimmd@snu.ac.kr.; Division of Endocrinology and Metabolism, Boramae Medical Center, Seoul, Republic of Korea. swkimmd@snu.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%22101608652%22">Bone research</searchLink> [Bone Res] 2026 Apr 02; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Apr 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22West+China+School+of+Stomatology%2C+Sichuan+University%22">West China School of Stomatology, Sichuan University </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101608652 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2095-4700 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220954700%22">20954700 </searchLink><i>NLM ISO Abbreviation: </i>Bone Res <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41413-026-00521-9
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        Text: English
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      – TitleFull: Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis.
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              Text: 2026 Apr 02
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