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Sensing and perturbing mammalian cell states with reprogrammable ADAR sensors (RADARS).

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Title: Sensing and perturbing mammalian cell states with reprogrammable ADAR sensors (RADARS).
Authors: Koob J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Jiang K; Mass General Brigham Gene and Cell Therapy Institute, Brigham and Women's Hospital, Boston, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Harvard Medical School, Harvard University, Boston, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Sgrizzi SR; Mass General Brigham Gene and Cell Therapy Institute, Brigham and Women's Hospital, Boston, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Harvard Medical School, Harvard University, Boston, MA, USA., Chen F; Broad Institute of MIT and Harvard, Cambridge, MA, USA. chenf@broadinstitute.org.; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. chenf@broadinstitute.org., Abudayyeh OO; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. omar@abudayyeh.science.; Mass General Brigham Gene and Cell Therapy Institute, Brigham and Women's Hospital, Boston, MA, USA. omar@abudayyeh.science.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. omar@abudayyeh.science.; Harvard Medical School, Harvard University, Boston, MA, USA. omar@abudayyeh.science., Gootenberg JS; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. jgoot@mit.edu.; Mass General Brigham Gene and Cell Therapy Institute, Brigham and Women's Hospital, Boston, MA, USA. jgoot@mit.edu.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. jgoot@mit.edu.; Harvard Medical School, Harvard University, Boston, MA, USA. jgoot@mit.edu.
Source: Nature protocols [Nat Protoc] 2026 Jul; Vol. 21 (7), pp. 3260-3285. Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE
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  Data: Sensing and perturbing mammalian cell states with reprogrammable ADAR sensors (RADARS).
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  Data: <searchLink fieldCode="AU" term="%22Koob+J%22">Koob J</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+K%22">Jiang K</searchLink>; Mass General Brigham Gene and Cell Therapy Institute, Brigham and Women's Hospital, Boston, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Harvard Medical School, Harvard University, Boston, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sgrizzi+SR%22">Sgrizzi SR</searchLink>; Mass General Brigham Gene and Cell Therapy Institute, Brigham and Women's Hospital, Boston, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Harvard Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. chenf@broadinstitute.org.; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. chenf@broadinstitute.org.<br /><searchLink fieldCode="AU" term="%22Abudayyeh+OO%22">Abudayyeh OO</searchLink>; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. omar@abudayyeh.science.; Mass General Brigham Gene and Cell Therapy Institute, Brigham and Women's Hospital, Boston, MA, USA. omar@abudayyeh.science.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. omar@abudayyeh.science.; Harvard Medical School, Harvard University, Boston, MA, USA. omar@abudayyeh.science.<br /><searchLink fieldCode="AU" term="%22Gootenberg+JS%22">Gootenberg JS</searchLink>; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. jgoot@mit.edu.; Mass General Brigham Gene and Cell Therapy Institute, Brigham and Women's Hospital, Boston, MA, USA. jgoot@mit.edu.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. jgoot@mit.edu.; Harvard Medical School, Harvard University, Boston, MA, USA. jgoot@mit.edu.
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  Data: <searchLink fieldCode="JN" term="%22101284307%22">Nature protocols</searchLink> [Nat Protoc] 2026 Jul; Vol. 21 (7), pp. 3260-3285. <i>Date of Electronic Publication: </i>2026 Apr 02.
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        Value: 10.1038/s41596-025-01305-x
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              Text: 2026 Jul
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