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Pathway-level profiling of the sepsis proteome reveals immune and transcriptional dysregulation.

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Title: Pathway-level profiling of the sepsis proteome reveals immune and transcriptional dysregulation.
Authors: Van Nynatten LR; Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Logan.VanNynatten@lhsc.on.ca.; Physiology and Pharmacology, Western University, London, ON, Canada. Logan.VanNynatten@lhsc.on.ca.; London Health Sciences Centre-Victoria Campus, 800 Commissioners Road East, London, ON, N6A 5W9, Canada. Logan.VanNynatten@lhsc.on.ca., Tweddell D; Computer Science, Western University, London, ON, Canada., Daley M; Computer Science, Western University, London, ON, Canada.; Epidemiology and Biostatistics, Western University, London, ON, Canada., Cepinskas G; Medical Biophysics, Western University, London, ON, Canada.; Anatomy and Cell Biology, Western University, London, ON, Canada.; London Health Sciences Centre Research Institute, Western University, London, ON, Canada., Basmaji J; Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Slessarev M; Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Fraser DD; Physiology and Pharmacology, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.; London Health Sciences Centre Research Institute, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.; Pediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.; Clinical Neurological Sciences, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.; Children's Health Research Institute, London, ON, Canada. douglas.fraser@lhsc.on.ca.; GSK Chair in Clinical Pharmacology, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.; London Health Sciences Centre-Victoria Campus, 800 Commissioners Road East, London, ON, N6A 5W9, Canada. douglas.fraser@lhsc.on.ca.
Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2026 Apr 02; Vol. 32 (1). Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE
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  Data: Pathway-level profiling of the sepsis proteome reveals immune and transcriptional dysregulation.
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  Data: <searchLink fieldCode="AU" term="%22Van+Nynatten+LR%22">Van Nynatten LR</searchLink>; Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Logan.VanNynatten@lhsc.on.ca.; Physiology and Pharmacology, Western University, London, ON, Canada. Logan.VanNynatten@lhsc.on.ca.; London Health Sciences Centre-Victoria Campus, 800 Commissioners Road East, London, ON, N6A 5W9, Canada. Logan.VanNynatten@lhsc.on.ca.<br /><searchLink fieldCode="AU" term="%22Tweddell+D%22">Tweddell D</searchLink>; Computer Science, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Daley+M%22">Daley M</searchLink>; Computer Science, Western University, London, ON, Canada.; Epidemiology and Biostatistics, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cepinskas+G%22">Cepinskas G</searchLink>; Medical Biophysics, Western University, London, ON, Canada.; Anatomy and Cell Biology, Western University, London, ON, Canada.; London Health Sciences Centre Research Institute, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Basmaji+J%22">Basmaji J</searchLink>; Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Slessarev+M%22">Slessarev M</searchLink>; Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Fraser+DD%22">Fraser DD</searchLink>; Physiology and Pharmacology, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.; London Health Sciences Centre Research Institute, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.; Pediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.; Clinical Neurological Sciences, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.; Children's Health Research Institute, London, ON, Canada. douglas.fraser@lhsc.on.ca.; GSK Chair in Clinical Pharmacology, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.; London Health Sciences Centre-Victoria Campus, 800 Commissioners Road East, London, ON, N6A 5W9, Canada. douglas.fraser@lhsc.on.ca.
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