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Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant Oligodendroglioma.

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Title: Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant Oligodendroglioma.
Authors: Larion M; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Muley H; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Zaibaq F; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Zhang M; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Davis D; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Kruhlak M; National Cancer Institute., Mathur S; Office of Science and Technology Resources, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Lita A; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Song H; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Zhang W; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Wong Z; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Harmon T; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Zhang L; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Cam-El Makranz C; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Li A; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Karadimov G; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Lang F; NCI，National Institutes of Health., Herold-Mende C; University of Heidelberg., Yang C; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health., Dowdy T; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.
Source: Research square [Res Sq] 2026 Mar 25. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant Oligodendroglioma.
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  Data: <searchLink fieldCode="AU" term="%22Larion+M%22">Larion M</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Muley+H%22">Muley H</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Zaibaq+F%22">Zaibaq F</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Davis+D%22">Davis D</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Kruhlak+M%22">Kruhlak M</searchLink>; National Cancer Institute.<br /><searchLink fieldCode="AU" term="%22Mathur+S%22">Mathur S</searchLink>; Office of Science and Technology Resources, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lita+A%22">Lita A</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Song+H%22">Song H</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Wong+Z%22">Wong Z</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Harmon+T%22">Harmon T</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Cam-El+Makranz+C%22">Cam-El Makranz C</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Li+A%22">Li A</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Karadimov+G%22">Karadimov G</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Lang+F%22">Lang F</searchLink>; NCI，National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Herold-Mende+C%22">Herold-Mende C</searchLink>; University of Heidelberg.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.<br /><searchLink fieldCode="AU" term="%22Dowdy+T%22">Dowdy T</searchLink>; Center for Cancer Research (CCR), National Cancer Institute, National Institutes of Health.
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              Text: 2026 Mar 25
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