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Multimodal analysis of cell-free DNA identifies epigenetic biomarkers for amyotrophic lateral sclerosis diagnosis and progression.

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Title: Multimodal analysis of cell-free DNA identifies epigenetic biomarkers for amyotrophic lateral sclerosis diagnosis and progression.
Authors: Michels S; Department of Neurology, University of Ulm, Ulm, Germany., Chen C; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA., Ruf WP; Department of Neurology, University of Ulm, Ulm, Germany., Garcia MMG; Department of Pathology & Laboratory Medicine, University of California, Irvine; Irvine, CA, USA., Arnold FJ; Department of Pathology & Laboratory Medicine, University of California, Irvine; Irvine, CA, USA., Wu Z; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA., Bennett CL; Department of Pathology & Laboratory Medicine, University of California, Irvine; Irvine, CA, USA., Shams D; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA., Thompson LM; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA.; Department of Psychiatry & Human Behavior, University of California, Irvine; Irvine, CA, USA.; Department of Neurobiology & Behavior, University of California, Irvine; Irvine, CA, USA.; UCI Institute for Memory Impairment & Neurological Disorders.; UCI Stem Cell Research Center.; UCI Center for Neurotherapeutics, University of California, Irvine; Irvine, CA, USA., Walker AC; Department of Neuroscience, Mayo Clinic; Jacksonville, Florida, USA., Dickson DW; Department of Neuroscience, Mayo Clinic; Jacksonville, Florida, USA.; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine; Jacksonville, Florida, USA., Petrucelli L; Department of Neuroscience, Mayo Clinic; Jacksonville, Florida, USA.; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine; Jacksonville, Florida, USA., Dorst J; Department of Neurology, University of Ulm, Ulm, Germany., Prudencio M; Department of Neuroscience, Mayo Clinic; Jacksonville, Florida, USA.; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine; Jacksonville, Florida, USA., Li W; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA., La Spada AR; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA.; Department of Pathology & Laboratory Medicine, University of California, Irvine; Irvine, CA, USA.; Department of Neurobiology & Behavior, University of California, Irvine; Irvine, CA, USA.; UCI Institute for Memory Impairment & Neurological Disorders.; UCI Stem Cell Research Center.; UCI Center for Neurotherapeutics, University of California, Irvine; Irvine, CA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 23. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Multimodal analysis of cell-free DNA identifies epigenetic biomarkers for amyotrophic lateral sclerosis diagnosis and progression.
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  Data: <searchLink fieldCode="AU" term="%22Michels+S%22">Michels S</searchLink>; Department of Neurology, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ruf+WP%22">Ruf WP</searchLink>; Department of Neurology, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Garcia+MMG%22">Garcia MMG</searchLink>; Department of Pathology & Laboratory Medicine, University of California, Irvine; Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Arnold+FJ%22">Arnold FJ</searchLink>; Department of Pathology & Laboratory Medicine, University of California, Irvine; Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+CL%22">Bennett CL</searchLink>; Department of Pathology & Laboratory Medicine, University of California, Irvine; Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shams+D%22">Shams D</searchLink>; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+LM%22">Thompson LM</searchLink>; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA.; Department of Psychiatry & Human Behavior, University of California, Irvine; Irvine, CA, USA.; Department of Neurobiology & Behavior, University of California, Irvine; Irvine, CA, USA.; UCI Institute for Memory Impairment & Neurological Disorders.; UCI Stem Cell Research Center.; UCI Center for Neurotherapeutics, University of California, Irvine; Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Walker+AC%22">Walker AC</searchLink>; Department of Neuroscience, Mayo Clinic; Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Dickson+DW%22">Dickson DW</searchLink>; Department of Neuroscience, Mayo Clinic; Jacksonville, Florida, USA.; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine; Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Petrucelli+L%22">Petrucelli L</searchLink>; Department of Neuroscience, Mayo Clinic; Jacksonville, Florida, USA.; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine; Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Dorst+J%22">Dorst J</searchLink>; Department of Neurology, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Prudencio+M%22">Prudencio M</searchLink>; Department of Neuroscience, Mayo Clinic; Jacksonville, Florida, USA.; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine; Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22La+Spada+AR%22">La Spada AR</searchLink>; Department of Biological Chemistry, University of California, Irvine; Irvine, CA, USA.; Department of Pathology & Laboratory Medicine, University of California, Irvine; Irvine, CA, USA.; Department of Neurobiology & Behavior, University of California, Irvine; Irvine, CA, USA.; UCI Institute for Memory Impairment & Neurological Disorders.; UCI Stem Cell Research Center.; UCI Center for Neurotherapeutics, University of California, Irvine; Irvine, CA, USA.
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