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Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation.

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Title: Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation.
Authors: Replogle JM; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Marks JD; Medical Scientist Training Program, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA., Fernandez MG; Department of Biophysics, University of Michigan, Ann Arbor, MI 48109, USA.; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Yuan H; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Yu D; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA., Winters E; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Jawahar VM; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Deshmukh R; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Sutanto R; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Kowal I; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA., Frankenfield A; Department of Chemistry, George Washington University, Washington, DC 20052, USA., Shi R; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Carlomagno Y; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Jansen-West K; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Todd TW; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Kopach A; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Sandra Ndayambaje I; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Qi YA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA., Shantaraman A; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA., Pozo-Cabanell I; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Sheth U; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Yue M; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Duong D; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA., Ferguson SM; Department of Cell Biology, Department of Neuroscience, Program in Cellular Neuroscience, Neurodegeneration and Repair, Wu Tsai Institute, Stephen & Denise Adams Center for Parkinson's Disease Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA., Damme M; Faculty of Chemistry, Biochemistry I (BCI), University of Bielefeld, Bielefeld 33615, Germany.; Institute of Biochemistry, Christian-Albrechts-University Kiel, Kiel 24118, Germany., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN 55902, USA., Day GS; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Kellman B; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA 02139, USA., Skarnes WC; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN 55902, USA., Josephs KA; Department of Neurology, Mayo Clinic, Rochester, MN 55902, USA., Graff-Radford NR; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., McDonough JA; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Prudencio M; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Barmada SJ; Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA., Zhang Y; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Hao L; Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, USA., DeTure M; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Rawlinson B; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Engelberg-Cook E; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Casey MC; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Perez N; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Dickson DW; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Wingo A; Department of Psychiatry, University of California, Davis, Sacramento, CA 95817, USA.; VA Northern California Healthcare System, Sacramento, CA 95655, USA., Liu Y; Department of Neurology, University of California, Davis, Sacramento, CA 95817, USA., Seyfried NT; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA., Wingo TS; Department of Neurology, University of California, Davis, Sacramento, CA 95817, USA.; Alzheimer's Disease Research Center, University of California, Davis, Sacramento, CA 95817, USA., Mosalaganti S; Department of Biophysics, University of Michigan, Ann Arbor, MI 48109, USA.; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA., Petrucelli L; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.; Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Ward ME; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 28. Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation.
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  Data: <searchLink fieldCode="AU" term="%22Replogle+JM%22">Replogle JM</searchLink>; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Marks+JD%22">Marks JD</searchLink>; Medical Scientist Training Program, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.<br /><searchLink fieldCode="AU" term="%22Fernandez+MG%22">Fernandez MG</searchLink>; Department of Biophysics, University of Michigan, Ann Arbor, MI 48109, USA.; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+H%22">Yuan H</searchLink>; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Yu+D%22">Yu D</searchLink>; Neuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.<br /><searchLink fieldCode="AU" term="%22Winters+E%22">Winters E</searchLink>; 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          Identifiers:
            – Type: issn-electronic
              Value: 2692-8205
          Titles:
            – TitleFull: BioRxiv : the preprint server for biology
              Type: main
ResultId 1