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A uniquely leptin sensitive hypothalamic neuron population limits hyperphagia and weight gain in diet-induced obesity.

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Title: A uniquely leptin sensitive hypothalamic neuron population limits hyperphagia and weight gain in diet-induced obesity.
Authors: Belmont-Rausch DM; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Kapel BS; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Tomlinson AJ; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Ding C; Research Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany., Duensing AM; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Coester B; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Mathiesen CV; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Cabot L; Research Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany., Brown JM; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Kruse CH; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Clemmensen C; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Schwartz MW; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington at South Lake Union, Seattle, Washington., Fenselau H; Research Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany., Myers MG Jr; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Pers TH; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 29. Date of Electronic Publication: 2026 Mar 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41929083
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A uniquely leptin sensitive hypothalamic neuron population limits hyperphagia and weight gain in diet-induced obesity.
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  Data: <searchLink fieldCode="AU" term="%22Belmont-Rausch+DM%22">Belmont-Rausch DM</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kapel+BS%22">Kapel BS</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Tomlinson+AJ%22">Tomlinson AJ</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Ding+C%22">Ding C</searchLink>; Research Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Duensing+AM%22">Duensing AM</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Coester+B%22">Coester B</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Mathiesen+CV%22">Mathiesen CV</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Cabot+L%22">Cabot L</searchLink>; Research Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Brown+JM%22">Brown JM</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kruse+CH%22">Kruse CH</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Clemmensen+C%22">Clemmensen C</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Schwartz+MW%22">Schwartz MW</searchLink>; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington at South Lake Union, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Fenselau+H%22">Fenselau H</searchLink>; Research Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Myers+MG+Jr%22">Myers MG Jr</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Pers+TH%22">Pers TH</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
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