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Danshensu ameliorates doxorubicin cardiotoxicity by attenuating oxidative stress and JNK-mediated mitochondrial dysfunction.

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Title: Danshensu ameliorates doxorubicin cardiotoxicity by attenuating oxidative stress and JNK-mediated mitochondrial dysfunction.
Authors: Wang X; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Huang W; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Shen L; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Zheng L; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Gu L; C Ray Therapeutics (Chengdu) Co.,Ltd., Chengdu, Sichuan, 610041, China., Lin L; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Li L; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Liu L; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Wang Y; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Li X; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Mao Y; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Liu X; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Chen Y; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Kong J; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Jiang Q; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Yan X; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Li R; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Sichuan Key Laboratory of TCM Regulating Metabolic Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610072, PR China., Li H; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Zhang J; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Zhang R; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Wang F; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Guo Y; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Cardiovascular Surgery and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China., Jiang W; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address: wcumsjw@scu.edu.cn.
Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2026 Jun; Vol. 155, pp. 158131. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41930814
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Danshensu ameliorates doxorubicin cardiotoxicity by attenuating oxidative stress and JNK-mediated mitochondrial dysfunction.
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  Data: <searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Shen+L%22">Shen L</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Zheng+L%22">Zheng L</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Gu+L%22">Gu L</searchLink>; C Ray Therapeutics (Chengdu) Co.,Ltd., Chengdu, Sichuan, 610041, China.<br /><searchLink fieldCode="AU" term="%22Lin+L%22">Lin L</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Mao+Y%22">Mao Y</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Kong+J%22">Kong J</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Jiang+Q%22">Jiang Q</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Yan+X%22">Yan X</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Sichuan Key Laboratory of TCM Regulating Metabolic Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610072, PR China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Cardiovascular Surgery and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.<br /><searchLink fieldCode="AU" term="%22Jiang+W%22">Jiang W</searchLink>; Department of Cardiovascular Surgery and Institute of Cardiovascular Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address: wcumsjw@scu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229438794%22">Phytomedicine : international journal of phytotherapy and phytopharmacology</searchLink> [Phytomedicine] 2026 Jun; Vol. 155, pp. 158131. <i>Date of Electronic Publication: </i>2026 Mar 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Urban+%26+Fischer+Verlag%22">Urban & Fischer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9438794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1618-095X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209447113%22">09447113 </searchLink><i>NLM ISO Abbreviation: </i>Phytomedicine <i>Subsets: </i>MEDLINE
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