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Discovery of Non-prostanoid EP4 Agonists for the Treatment of Inflammatory Bowel Disease.

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Title: Discovery of Non-prostanoid EP4 Agonists for the Treatment of Inflammatory Bowel Disease.
Authors: Perez HL; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Dewnani S; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Spronk SA; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Xiao HY; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Li L; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Abousleiman M; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Sum CS; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Garcia-Calvo M; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Yu F; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Anderson B; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Arey BJ; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Khan R; Bristol Myers Squibb Biocon Research and Development Center (BBRC), Bangalore 560099, India., Bokka CS; Bristol Myers Squibb Biocon Research and Development Center (BBRC), Bangalore 560099, India., Muthukumar Y; Bristol Myers Squibb Biocon Research and Development Center (BBRC), Bangalore 560099, India., Ghosh K; Bristol Myers Squibb Biocon Research and Development Center (BBRC), Bangalore 560099, India., Wang T; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Krause CM; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Murray J; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Vernon T; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Chandran R; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Obermeier MT; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Guarino VR; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., King T; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Li J; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Armstrong L; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Khandelwal P; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Prack M; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Marcoux D; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Gerritz S; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Pitts WJ; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Dyckman AJ; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Borzilleri RM; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Dzierba C; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Xie JH; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Struthers M; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Shaw P; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Holmes D; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Hart AC; Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Sherwood TC; Bristol Myers Squibb, Princeton, New Jersey 08543, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9406-9440. Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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