Lactic acid drives NLRP3 inflammasome activation and caspase-1-like cytokine cleavage via intracellular acidification.
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| Title: | Lactic acid drives NLRP3 inflammasome activation and caspase-1-like cytokine cleavage via intracellular acidification. |
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| Authors: | Lin HA; Department of Internal Medicine, School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.; Department of Internal Medicine, Songshan Branch of Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan., Lin HC; Department of Pathology, School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.; Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan., Tsai MH; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.; Department of Internal Medicine, Songshan Branch of Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan., Chen YJ; Department of Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan.; Department of Radiation Oncology, MacKay Memorial Hospital, Taipei, Taiwan.; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, Taiwan.; Department of Artificial Intelligence and Medical Application, MacKay Junior College of Medicine, Nursing and Management, Taipei, Taiwan.; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan., Bao BY; Department of Pharmacy, China Medical University, Taichung, Taiwan., Tsai KJ; Department of Laboratory Medicine, MacKay Memorial Hospital, Taipei, Taiwan.; Department of Nursing, College of Nursing, MacKay Medical University, New Taipei City, Taiwan., Shih CT; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, Taiwan., Yu JS; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan., Chien KY; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.; Department of Biochemistry and Molecular Biology, Chang Gung University, Taoyuan, Taiwan.; Clinical Proteomics Core Laboratory, LinKou Chang Gung Memorial Hospital, Taoyuan, Taiwan., Huang KY; Graduate Institute of Pathology and Parasitology, College of Medicine, National Defense Medical University, Taipei, Taiwan., Ojcius DM; Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USA., Chen LC; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, Taiwan. lihchyang@mmu.edu.tw.; Institute of Biomedical Science, College of Medicine, MacKay Medical University, New Taipei City, Taiwan. lihchyang@mmu.edu.tw.; Department of Optometry, College of Medicine, MacKay Medical University, New Taipei City, Taiwan. lihchyang@mmu.edu.tw. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Apr 03; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41932879 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Lactic acid drives NLRP3 inflammasome activation and caspase-1-like cytokine cleavage via intracellular acidification. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lin+HA%22">Lin HA</searchLink>; Department of Internal Medicine, School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.; Department of Internal Medicine, Songshan Branch of Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HC%22">Lin HC</searchLink>; Department of Pathology, School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.; Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+MH%22">Tsai MH</searchLink>; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.; Department of Internal Medicine, Songshan Branch of Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; Department of Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan.; Department of Radiation Oncology, MacKay Memorial Hospital, Taipei, Taiwan.; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, Taiwan.; Department of Artificial Intelligence and Medical Application, MacKay Junior College of Medicine, Nursing and Management, Taipei, Taiwan.; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Bao+BY%22">Bao BY</searchLink>; Department of Pharmacy, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+KJ%22">Tsai KJ</searchLink>; Department of Laboratory Medicine, MacKay Memorial Hospital, Taipei, Taiwan.; Department of Nursing, College of Nursing, MacKay Medical University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shih+CT%22">Shih CT</searchLink>; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+JS%22">Yu JS</searchLink>; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chien+KY%22">Chien KY</searchLink>; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.; Department of Biochemistry and Molecular Biology, Chang Gung University, Taoyuan, Taiwan.; Clinical Proteomics Core Laboratory, LinKou Chang Gung Memorial Hospital, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KY%22">Huang KY</searchLink>; Graduate Institute of Pathology and Parasitology, College of Medicine, National Defense Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ojcius+DM%22">Ojcius DM</searchLink>; Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+LC%22">Chen LC</searchLink>; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, Taiwan. lihchyang@mmu.edu.tw.; Institute of Biomedical Science, College of Medicine, MacKay Medical University, New Taipei City, Taiwan. lihchyang@mmu.edu.tw.; Department of Optometry, College of Medicine, MacKay Medical University, New Taipei City, Taiwan. lihchyang@mmu.edu.tw. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Apr 03; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Apr 03. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41932879 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41419-026-08708-y Languages: – Code: eng Text: English Titles: – TitleFull: Lactic acid drives NLRP3 inflammasome activation and caspase-1-like cytokine cleavage via intracellular acidification. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lin HA – PersonEntity: Name: NameFull: Lin HC – PersonEntity: Name: NameFull: Tsai MH – PersonEntity: Name: NameFull: Chen YJ – PersonEntity: Name: NameFull: Bao BY – PersonEntity: Name: NameFull: Tsai KJ – PersonEntity: Name: NameFull: Shih CT – PersonEntity: Name: NameFull: Yu JS – PersonEntity: Name: NameFull: Chien KY – PersonEntity: Name: NameFull: Huang KY – PersonEntity: Name: NameFull: Ojcius DM – PersonEntity: Name: NameFull: Chen LC IsPartOfRelationships: – BibEntity: Dates: – D: 03 M: 04 Text: 2026 Apr 03 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-4889 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Cell death & disease Type: main |
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