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Single-cell transcriptomics reveals FXR1 as an actionable target for siRNA therapy in ovarian cancer.

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Title: Single-cell transcriptomics reveals FXR1 as an actionable target for siRNA therapy in ovarian cancer.
Authors: George J; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA., Ma X; Division of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, USA., Kadamberi IP; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA., Nair A; Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Mittal S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA., Hashemi E; Versiti Blood Research Institute, Milwaukee, WI, USA., Kumar S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA., Singh M; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA., Geethadevi A; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA., Pradeep M; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA., Nair A; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA., Tsaih SW; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA., Jorns JM; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA., Malarkannan S; Versiti Blood Research Institute, Milwaukee, WI, USA., Dietlein F; Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Lin CW; Division of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, USA. chlin@mcw.edu., Pradeep S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA. spradeep@mcw.edu., Chaluvally-Raghavan P; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA. pchaluvally@mcw.edu.
Source: Nature communications [Nat Commun] 2026 Apr 03; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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