An international, double-blind, randomized, placebo-controlled clinical trial of adjunctive trimetazidine to treat people with bipolar depression (the TIDE trial) protocol.

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Title: An international, double-blind, randomized, placebo-controlled clinical trial of adjunctive trimetazidine to treat people with bipolar depression (the TIDE trial) protocol.
Authors: Kim JH; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia. jee.kim@deakin.edu.au.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia. jee.kim@deakin.edu.au., Park CHJ; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia., Reddy PV; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Khanra S; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Arumugham SS; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Venkatasubramanian G; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Debnath M; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Arasappa R; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Ashton MM; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia., Panizzutti B; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia., Turner A; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia., Tholasappa V; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Shukla D; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Sadashiva ST; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Raj J; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Dombale S; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Dean O; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia., Mohebbi M; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.; Biostatistics Unit, Deakin University, Geelong, VIC, 3220, Australia., Vieta E; Bipolar and Depressives Disorders Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain., Pacchiarotti I; Bipolar and Depressives Disorders Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain., Umesh S; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Walder K; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia., Yatham L; Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2A1, Canada., Baek JH; Department of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Gangnam-Gu, Seoul, 06351, Korea., Goyal N; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Reddy YCJ; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Kesavan M; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Berk M; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia. michael.berk@deakin.edu.au.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia. michael.berk@deakin.edu.au.; Department of Psychiatry, University of Melbourne, Parkville, 3010, Australia. michael.berk@deakin.edu.au.; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, 3010, Australia. michael.berk@deakin.edu.au.
Source: BMC psychiatry [BMC Psychiatry] 2026 Apr 03; Vol. 26 (1). Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1471-244X
DOI:10.1186/s12888-026-08026-9