An international, double-blind, randomized, placebo-controlled clinical trial of adjunctive trimetazidine to treat people with bipolar depression (the TIDE trial) protocol.
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| Title: | An international, double-blind, randomized, placebo-controlled clinical trial of adjunctive trimetazidine to treat people with bipolar depression (the TIDE trial) protocol. |
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| Authors: | Kim JH; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia. jee.kim@deakin.edu.au.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia. jee.kim@deakin.edu.au., Park CHJ; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia., Reddy PV; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Khanra S; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Arumugham SS; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Venkatasubramanian G; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Debnath M; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Arasappa R; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Ashton MM; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia., Panizzutti B; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia., Turner A; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia., Tholasappa V; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Shukla D; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Sadashiva ST; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Raj J; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Dombale S; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Dean O; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia., Mohebbi M; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.; Biostatistics Unit, Deakin University, Geelong, VIC, 3220, Australia., Vieta E; Bipolar and Depressives Disorders Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain., Pacchiarotti I; Bipolar and Depressives Disorders Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain., Umesh S; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Walder K; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia., Yatham L; Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2A1, Canada., Baek JH; Department of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Gangnam-Gu, Seoul, 06351, Korea., Goyal N; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India., Reddy YCJ; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Kesavan M; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India., Berk M; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia. michael.berk@deakin.edu.au.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia. michael.berk@deakin.edu.au.; Department of Psychiatry, University of Melbourne, Parkville, 3010, Australia. michael.berk@deakin.edu.au.; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, 3010, Australia. michael.berk@deakin.edu.au. |
| Source: | BMC psychiatry [BMC Psychiatry] 2026 Apr 03; Vol. 26 (1). Date of Electronic Publication: 2026 Apr 03. |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41933313 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: An international, double-blind, randomized, placebo-controlled clinical trial of adjunctive trimetazidine to treat people with bipolar depression (the TIDE trial) protocol. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kim+JH%22">Kim JH</searchLink>; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia. jee.kim@deakin.edu.au.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia. jee.kim@deakin.edu.au.<br /><searchLink fieldCode="AU" term="%22Park+CHJ%22">Park CHJ</searchLink>; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.<br /><searchLink fieldCode="AU" term="%22Reddy+PV%22">Reddy PV</searchLink>; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India.<br /><searchLink fieldCode="AU" term="%22Khanra+S%22">Khanra S</searchLink>; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India.<br /><searchLink fieldCode="AU" term="%22Arumugham+SS%22">Arumugham SS</searchLink>; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India.<br /><searchLink fieldCode="AU" term="%22Venkatasubramanian+G%22">Venkatasubramanian G</searchLink>; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India.<br /><searchLink fieldCode="AU" term="%22Debnath+M%22">Debnath M</searchLink>; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India.<br /><searchLink fieldCode="AU" term="%22Arasappa+R%22">Arasappa R</searchLink>; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India.<br /><searchLink fieldCode="AU" term="%22Ashton+MM%22">Ashton MM</searchLink>; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.<br /><searchLink fieldCode="AU" term="%22Panizzutti+B%22">Panizzutti B</searchLink>; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.<br /><searchLink fieldCode="AU" term="%22Turner+A%22">Turner A</searchLink>; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.<br /><searchLink fieldCode="AU" term="%22Tholasappa+V%22">Tholasappa V</searchLink>; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India.<br /><searchLink fieldCode="AU" term="%22Shukla+D%22">Shukla D</searchLink>; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India.<br /><searchLink fieldCode="AU" term="%22Sadashiva+ST%22">Sadashiva ST</searchLink>; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India.<br /><searchLink fieldCode="AU" term="%22Raj+J%22">Raj J</searchLink>; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India.<br /><searchLink fieldCode="AU" term="%22Dombale+S%22">Dombale S</searchLink>; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India.<br /><searchLink fieldCode="AU" term="%22Dean+O%22">Dean O</searchLink>; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Mohebbi+M%22">Mohebbi M</searchLink>; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.; Biostatistics Unit, Deakin University, Geelong, VIC, 3220, Australia.<br /><searchLink fieldCode="AU" term="%22Vieta+E%22">Vieta E</searchLink>; Bipolar and Depressives Disorders Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pacchiarotti+I%22">Pacchiarotti I</searchLink>; Bipolar and Depressives Disorders Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Umesh+S%22">Umesh S</searchLink>; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India.<br /><searchLink fieldCode="AU" term="%22Walder+K%22">Walder K</searchLink>; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.<br /><searchLink fieldCode="AU" term="%22Yatham+L%22">Yatham L</searchLink>; Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2A1, Canada.<br /><searchLink fieldCode="AU" term="%22Baek+JH%22">Baek JH</searchLink>; Department of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Gangnam-Gu, Seoul, 06351, Korea.<br /><searchLink fieldCode="AU" term="%22Goyal+N%22">Goyal N</searchLink>; Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, 834006, India.<br /><searchLink fieldCode="AU" term="%22Reddy+YCJ%22">Reddy YCJ</searchLink>; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India.<br /><searchLink fieldCode="AU" term="%22Kesavan+M%22">Kesavan M</searchLink>; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, 560029, India.<br /><searchLink fieldCode="AU" term="%22Berk+M%22">Berk M</searchLink>; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia. michael.berk@deakin.edu.au.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia. michael.berk@deakin.edu.au.; Department of Psychiatry, University of Melbourne, Parkville, 3010, Australia. michael.berk@deakin.edu.au.; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, 3010, Australia. michael.berk@deakin.edu.au. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100968559%22">BMC psychiatry</searchLink> [BMC Psychiatry] 2026 Apr 03; Vol. 26 (1). <i>Date of Electronic Publication: </i>2026 Apr 03. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial Protocol – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100968559 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1471-244X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221471244X%22">1471244X </searchLink><i>NLM ISO Abbreviation: </i>BMC Psychiatry <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41933313 |
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