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Global burden of cerebral small vessel disease determined from large MRI studies: A systematic review and meta-analysis.

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Title: Global burden of cerebral small vessel disease determined from large MRI studies: A systematic review and meta-analysis.
Authors: Lam BYK; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong., Cai Y; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong., Zheng H; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong., Wei J; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong., Akinyemi R; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Centre for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Neurology, University College Hospital, Ibadan, Nigeria.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Biessels GJ; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands., Brink HVD; J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Chen C; Memory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Duering M; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Antaros Medical AB, Mölndal, Sweden.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Gustafson D; Section for NeuroEpidemiology, Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA., Hilal S; J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Memory, Aging and Cognition Center, National University Health System, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., Ming Ho Hui V; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong., Kalaria R; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Kim S; Department of Neurology, Seoul National University College of Medicine and Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seoul, South Korea., Lam MLM; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong., de Leeuw FE; Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Radboudumc, Nijmegen, The Netherlands., Li ASM; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong., Markus HS; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Marseglia A; Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., O'Brien J; Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Pantoni L; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.; Department of Neurorehabilitation Sciences, Casa di Cura Igea, Milan, Italy., Sachdev PS; Centre for Healthy Brain Ageing and School of Clinical Medicine, The University of New South Wales, Sydney, NSW, Australia.; Neuropsychiatric Institute, School of Psychiatry, The University of New South Wales, Sydney, NSW, Australia., Smith EE; Division of Neurology, Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., Wardlaw JM; Centre for Clinical Brain Sciences, Edinburgh Imaging, Institute of Neuroscience and Cardiovascular Research, and UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Wong A; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong., Ko H; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong., Mok VCT; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong.
Source: International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2026 Apr 04, pp. 17474930261441916. Date of Electronic Publication: 2026 Apr 04.
Publication Type: Journal Article; Review
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101274068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4949 (Electronic) Linking ISSN: 17474930 NLM ISO Abbreviation: Int J Stroke Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Global burden of cerebral small vessel disease determined from large MRI studies: A systematic review and meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Lam+BYK%22">Lam BYK</searchLink>; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Zheng+H%22">Zheng H</searchLink>; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Wei+J%22">Wei J</searchLink>; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Akinyemi+R%22">Akinyemi R</searchLink>; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Centre for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Neurology, University College Hospital, Ibadan, Nigeria.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Biessels+GJ%22">Biessels GJ</searchLink>; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Brink+HVD%22">Brink HVD</searchLink>; J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Memory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Duering+M%22">Duering M</searchLink>; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Antaros Medical AB, Mölndal, Sweden.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gustafson+D%22">Gustafson D</searchLink>; Section for NeuroEpidemiology, Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hilal+S%22">Hilal S</searchLink>; J. 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Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Kalaria+R%22">Kalaria R</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Neurology, Seoul National University College of Medicine and Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lam+MLM%22">Lam MLM</searchLink>; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.<br /><searchLink fieldCode="AU" term="%22de+Leeuw+FE%22">de Leeuw FE</searchLink>; Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Radboudumc, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Li+ASM%22">Li ASM</searchLink>; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. 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Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Mok+VCT%22">Mok VCT</searchLink>; Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Gerald Choa Neuroscience Institute, Margaret K.L. Cheung Research Centre for Management of Parkinsonism and Lau Tat-cheun Research Center of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong.
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